A Programmed Anti‐Inflammatory Nanoscaffold (PAIN) as a 3D Tool to Understand the Brain Injury Response

Maclean, F, Ims, G, Horne, M, Williams, R and Nisbet, D 2018, 'A Programmed Anti‐Inflammatory Nanoscaffold (PAIN) as a 3D Tool to Understand the Brain Injury Response', Advanced Materials, vol. 30, no. 50, 1805209, pp. 1-8.


Document type: Journal Article
Collection: Journal Articles

Title A Programmed Anti‐Inflammatory Nanoscaffold (PAIN) as a 3D Tool to Understand the Brain Injury Response
Author(s) Maclean, F
Ims, G
Horne, M
Williams, R
Nisbet, D
Year 2018
Journal name Advanced Materials
Volume number 30
Issue number 50
Article Number 1805209
Start page 1
End page 8
Total pages 8
Publisher Wiley - V C H Verlag GmbH & Co. KGaA
Abstract Immunology is the next frontier of nano/biomaterial science research, with the immune system determining the degree of tissue repair. However, the complexity of the inflammatory response represents a significant challenge that is essential to understand for the development of future therapies. Cell-instructive 3D culture environments are critical to improve our understanding of the link between the behavior and morphology of inflammatory cells and to remodel their response to injury. This study has taken two recent high-profile innovationsfunctional peptide-based hydrogels, and the inclusion of anti-inflammatory agents via coassemblyto make a programmed anti-inflammatory nanoscaffold (PAIN) with unusual and valuable properties that allows tissue-independent switching of the inflammatory cascade. Here, extraordinary durability of the anti-inflammatory agent allows, for the first time, the development of a 3D culture system that maintains the growth and cytoskeletal reorganization of brain tissue, while also facilitating the trophic behavior of brain cells for 22 d in vitro. Notably, this behavior was confirmed within an active scar site due to the unprecedented resilience to the presence of inflammatory cells and enzymes in the brain. Efficacy of the culture system is demonstrated via novel insights about inflammatory cell behavior, which would be impossible to obtain via in vivo experimentation.
Subject Biomaterials
DOI - identifier 10.1002/adma.201805209
Copyright notice © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
ISSN 1521-4095
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