Cu-Catalyzed Coupling of O-Acyl Oximes with Isatins: Domino Rearrangement Strategy for Direct Access to Quinoline-4-Carboxamides by C-N Bond Cleavage

Andhavaram, R, Chouhan, N, Ravi, O, Sridhar, B and Bathula, S 2018, 'Cu-Catalyzed Coupling of O-Acyl Oximes with Isatins: Domino Rearrangement Strategy for Direct Access to Quinoline-4-Carboxamides by C-N Bond Cleavage', European Journal of Organic Chemistry, vol. 2018, no. 23, pp. 2963-2971.


Document type: Journal Article
Collection: Journal Articles

Title Cu-Catalyzed Coupling of O-Acyl Oximes with Isatins: Domino Rearrangement Strategy for Direct Access to Quinoline-4-Carboxamides by C-N Bond Cleavage
Author(s) Andhavaram, R
Chouhan, N
Ravi, O
Sridhar, B
Bathula, S
Year 2018
Journal name European Journal of Organic Chemistry
Volume number 2018
Issue number 23
Start page 2963
End page 2971
Total pages 9
Publisher Wiley
Abstract A mild domino rearrangement strategy for the direct access to substituted quinoline‐4‐carboxamides has been developed. This copper‐catalyzed coupling reaction of O‐acyl oximes with isatins in the presence of molecular oxygen as the sole oxidizing agent proceeds through a ring expansion of the isatins through cleavage of the two CN bonds
Subject Organic Chemical Synthesis
Keyword(s) Copper
Domino reactions
Nitrogen heterocycles
Oximes
Ring expansion
DOI - identifier 10.1002/ejoc.201800501
Copyright notice © 2018 WILEY-VCH Verlag GmbH
ISSN 1434-193X
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