Hepatoprotective activity of Satwa, an Ayurvedic formulation, against alcohol-induced liver injury in rats

Chavan, T, Ghadge, A, Karandikar, M, Pandit, V, Ranjekar, P, Kulkarni, O, Kuvalekar, A and Mantri, N 2017, 'Hepatoprotective activity of Satwa, an Ayurvedic formulation, against alcohol-induced liver injury in rats', Alternative Therapies in Health and Medicine, vol. 23, no. 4, pp. 34-40.


Document type: Journal Article
Collection: Journal Articles

Title Hepatoprotective activity of Satwa, an Ayurvedic formulation, against alcohol-induced liver injury in rats
Author(s) Chavan, T
Ghadge, A
Karandikar, M
Pandit, V
Ranjekar, P
Kulkarni, O
Kuvalekar, A
Mantri, N
Year 2017
Journal name Alternative Therapies in Health and Medicine
Volume number 23
Issue number 4
Start page 34
End page 40
Total pages 7
Publisher InnoVision Health Media
Abstract Context . Guduchi Satwa is an Ayurvedic formulation prepared from Tinospora species. It has been used since ancient times to treat liver disorders. Objectives . The study intended to assess the hepatoprotective potential of Satwa prepared from 3 forms of Tinospora against alcohol-induced hepatotoxicity. Design . Male, albino Wistar rats were divided into 6 groups, with 6 rats each: 3 control groups-healthy controls, negative controls, and positive controls-and 3 intervention groups-Tinospora cordifolia, Tinospora sinensis, and Neem-Guduchi. Setting . The study was carried out at the Animal House facility of Bharati Vidyapeeth Deemed University's Medical College (Maharashtra, India). Intervention . Hepatotoxicity was induced by repeated dosing with alcohol for 15 d for all groups except for the healthy controls. To induce hepatotoxicity, the 5 groups received 1 mL of 30% alcohol PO per 100 g of body weight per day. The healthy controls and the negative controls received no hepatoprotective treatments. The other 4 groups received the dosing with alcohol 30 min after the hepatoprotective treatment, which they also received for 15 d: (1) positive controls-100 mg of silymarin per kg of body weight per day PO; (2) intervention group 1 (T cordifolia group)-200 mg of T cordifolia per kg of body weight per day PO; (3) intervention group 2 (T sinensis group)-200 mg of T sinensis per kg of body weight per day PO; and (4) intervention group 3 (Neem-Guduchi group)-200 mg of Neem-Guduchi per kg of body weight per day PO. Outcome Measures . Serum and liver tissue were used for biochemical analysis. Results . For the negative and positive control groups and the 3 intervention groups, the repeated dosing with alcohol produced elevations in the levels of liver-marker enzymes and changes in the lipid-profile status of the animals. Satwa from T cordifolia had a specific action in maintaining the lipid profile: total cholesterol, high-density lipoprotein, low-density lipoprotein, and ve
Subject Complementary and Alternative Medicine not elsewhere classified
ISSN 1078-6791
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