Brain damage of the preterm infant: New insights into the role of inflammation

Van Steenwinckel, J, Schang, A, Sigaut, S, Chhor, V, Degos, V, Hagberg, H, Baud, O, Fleiss, B and Gressens, P 2014, 'Brain damage of the preterm infant: New insights into the role of inflammation', Biochemical Society Transactions, vol. 42, no. 2, pp. 557-563.


Document type: Journal Article
Collection: Journal Articles

Title Brain damage of the preterm infant: New insights into the role of inflammation
Author(s) Van Steenwinckel, J
Schang, A
Sigaut, S
Chhor, V
Degos, V
Hagberg, H
Baud, O
Fleiss, B
Gressens, P
Year 2014
Journal name Biochemical Society Transactions
Volume number 42
Issue number 2
Start page 557
End page 563
Total pages 7
Publisher Portland Press Ltd.
Abstract Epidemiological studies have shown a strong association between perinatal infection/inflammation and brain damage in preterm infants and/or neurological handicap in survivors. Experimental studies have shown a causal effect of infection/inflammation on perinatal brain damage. Infection including inflammatory factors can disrupt programmes of brain development and, in particular, induce death and/or blockade of oligodendrocyte maturation, leading to myelin defects. Alternatively, in the so-called multiple-hit hypothesis, infection/inflammation can act as predisposing factors, making the brain more susceptible to a second stress (sensitization process), such as hypoxic-ischaemic or excitotoxic insults. Epidemiological data also suggest that perinatal exposure to inflammatory factors could predispose to long-term diseases including psychiatric disorders. ©The Authors Journal compilation ©2014 Biochemical Society.
Subject Innate Immunity
Neurology and Neuromuscular Diseases
Paediatrics
Keyword(s) Cerebral palsy
Neurodevelopment
Neuroinflammation
Oligodendrocyte
Perinatal brain damage
DOI - identifier 10.1042/BST20130284
Copyright notice © The Authors Journal compilation, 2014 Biochemical Society
ISSN 0300-5127
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