Long-term cerebral effects of perinatal inflammation

Chhor, V, Schang, A, Favrais, G, Fleiss, B and Gressens, P 2012, 'Long-term cerebral effects of perinatal inflammation', Archives de Pediatrie, vol. 19, no. 9, pp. 946-952.


Document type: Journal Article
Collection: Journal Articles

Title Long-term cerebral effects of perinatal inflammation
Author(s) Chhor, V
Schang, A
Favrais, G
Fleiss, B
Gressens, P
Year 2012
Journal name Archives de Pediatrie
Volume number 19
Issue number 9
Start page 946
End page 952
Total pages 7
Publisher Elsevier Masson
Abstract Perinatal inflammation can lead to fetal/neonatal inflammatory syndrome, a risk factor for brain lesions, especially in the white matter. Perinatal inflammation is associated with increased incidence of cerebral palsy in humans and animal models and there is a strong relationship with increased incidence of autism and schizophrenia in humans. Perinatal inflammation causes acute microglial and astroglial activation, blood-brain barrier dysfunction, and disrupts oligodendrocyte maturation leading to hypomyelination. Inflammation also sensitizes the brain to additional perinatal insults, including hypoxia-ischemia. Furthermore, long after the primary cause of inflammation has resolved, gliosis may also persist and predispose to neurodegenerative diseases including Alzheimer's and Parkinson's disease, but this relation is still hypothetical. Finding of acute and chronic changes in brain structure and function due to perinatal inflammation highlights the need for treatments. As gliosis appears to be involved in the acute and chronic effects of perinatal inflammation, modulating the glial phenotype may be an effective strategy to prevent damage to the brain.
Subject Innate Immunity
Neurology and Neuromuscular Diseases
Paediatrics
DOI - identifier 10.1016/j.arcped.2012.06.013
Copyright notice Ā© 2012 PublieĀ“ par Elsevier Masson SAS.
ISSN 0929-693X
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