Tertiary mechanisms of brain damage: A new hope for treatment of cerebral palsy?

Fleiss, B and Gressens, P 2012, 'Tertiary mechanisms of brain damage: A new hope for treatment of cerebral palsy?', The Lancet Neurology, vol. 11, no. 6, pp. 556-566.


Document type: Journal Article
Collection: Journal Articles

Title Tertiary mechanisms of brain damage: A new hope for treatment of cerebral palsy?
Author(s) Fleiss, B
Gressens, P
Year 2012
Journal name The Lancet Neurology
Volume number 11
Issue number 6
Start page 556
End page 566
Total pages 11
Publisher The Lancet Publishing Group
Abstract Cerebral palsy is caused by injury or developmental disturbances to the immature brain and leads to substantial motor, cognitive, and learning deficits. In addition to developmental disruption associated with the initial insult to the immature brain, injury processes can persist for many months or years. We suggest that these tertiary mechanisms of damage might include persistent inflammation and epigenetic changes. We propose that these processes are implicit in prevention of endogenous repair and regeneration and predispose patients to development of future cognitive dysfunction and sensitisation to further injury. We suggest that treatment of tertiary mechanisms of damage might be possible by various means, including preventing the repressive effects of microglia and astrocyte over-activation, recapitulating developmentally permissive epigenetic conditions, and using cell therapies to stimulate repair and regeneration Recognition of tertiary mechanisms of damage might be the first step in a complex translational task to tailor safe and effective therapies that can be used to treat the already developmentally disrupted brain long after an insult.
Subject Neurology and Neuromuscular Diseases
Paediatrics
DOI - identifier 10.1016/S1474-4422(12)70058-3
Copyright notice © 2012 Elsevier Ltd.
ISSN 1474-4422
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