Molecular mechanisms of neonatal brain injury

Thornton, C, Rousset, C, Kichev, A, Miyakuni, Y, Vontell, R, Baburamani, A, Fleiss, B, Gressens, P and Hagberg, H 2012, 'Molecular mechanisms of neonatal brain injury', Neurology Research International, vol. 2012, pp. 1-16.


Document type: Journal Article
Collection: Journal Articles

Title Molecular mechanisms of neonatal brain injury
Author(s) Thornton, C
Rousset, C
Kichev, A
Miyakuni, Y
Vontell, R
Baburamani, A
Fleiss, B
Gressens, P
Hagberg, H
Year 2012
Journal name Neurology Research International
Volume number 2012
Start page 1
End page 16
Total pages 16
Publisher Hindawi Publishing Corporation
Abstract Fetal/neonatal brain injury is an important cause of neurological disability. Hypoxia-ischemia and excitotoxicity are considered important insults, and, in spite of their acute nature, brain injury develops over a protracted time period during the primary, secondary, and tertiary phases. The concept that most of the injury develops with a delay after the insult makes it possible to provide effective neuroprotective treatment after the insult. Indeed, hypothermia applied within 6 hours after birth in neonatal encephalopathy reduces neurological disability in clinical trials. In order to develop the next generation of treatment, we need to know more about the pathophysiological mechanism during the secondary and tertiary phases of injury. We review some of the critical molecular events related to mitochondrial dysfunction and apoptosis during the secondary phase and report some recent evidence that intervention may be feasible also days-weeks after the insult.
Subject Innate Immunity
Neurology and Neuromuscular Diseases
Paediatrics
DOI - identifier 10.1155/2012/506320
Copyright notice © 2012 Claire Thornton et al.
ISSN 2090-1852
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