Facile and rapid ruthenium mediated photo-crosslinking of Bombyx mori silk fibroin

Whittaker, J, Choudhury, N, Dutta, N and Zannettino, A 2014, 'Facile and rapid ruthenium mediated photo-crosslinking of Bombyx mori silk fibroin', Journal of Materials Chemistry B, vol. 2, no. 37, pp. 6259-6270.

Document type: Journal Article
Collection: Journal Articles

Title Facile and rapid ruthenium mediated photo-crosslinking of Bombyx mori silk fibroin
Author(s) Whittaker, J
Choudhury, N
Dutta, N
Zannettino, A
Year 2014
Journal name Journal of Materials Chemistry B
Volume number 2
Issue number 37
Start page 6259
End page 6270
Total pages 12
Publisher Royal Society of Chemistry
Abstract A facile and rapid ruthenium catalysed photo-crosslinking method was employed to prepare Bombyx mori silk fibroin hydrogels for the first time that may be used for biomedical applications. The gels have been characterised by differential scanning calorimetry (DSC), dynamic mechanical analysis (DMA), photo-acoustic Fourier transform infrared spectroscopy (PA-FTIR), and X-ray diffraction (XRD). We have reported the tuning of the properties of the chemically crosslinked gels through hydration level. DSC and DMA measurements have shown that the molecular chain dynamics and mechanical properties are dependent on the moisture/water content. The structural changes upon gelation were examined through the use of DSC, PA-FTIR and XRD, which confirmed that the gels were less crystalline than the original silk powder. Finally, the biocompatibility and hence, the potential tissue engineering application of the silk fibroin hydrogel was also assessed by culturing chondrocyte progenitor cells for up to one week on the engineered fibroin surfaces.
Subject Biomaterials
Chemical Engineering not elsewhere classified
DOI - identifier 10.1039/c4tb00698d
Copyright notice © the Partner Organisations 2014.
ISSN 2050-7518
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