An16-resilin: An advanced multi-stimuli-responsive resilin-mimetic protein polymer

Balu, R, Dutta, N, Choudhury, N, Elvin, C, Lyons, R, Knott, R and Hill, A 2014, 'An16-resilin: An advanced multi-stimuli-responsive resilin-mimetic protein polymer', Acta Biomaterialia, vol. 10, no. 11, pp. 4768-4777.

Document type: Journal Article
Collection: Journal Articles

Title An16-resilin: An advanced multi-stimuli-responsive resilin-mimetic protein polymer
Author(s) Balu, R
Dutta, N
Choudhury, N
Elvin, C
Lyons, R
Knott, R
Hill, A
Year 2014
Journal name Acta Biomaterialia
Volume number 10
Issue number 11
Start page 4768
End page 4777
Total pages 10
Publisher Elsevier B.V.
Abstract Engineered protein polymers that display responsiveness to multiple stimuli are emerging as a promising class of soft material with unprecedented functionality. The remarkable advancement in genetic engineering and biosynthesis has created the opportunity for precise control over the amino acid sequence, size, structure and resulting functions of such biomimetic proteins. Herein, we describe the multi-stimuli-responsive characteristics of a resilin-mimetic protein, An16-resilin (An16), derived from the consensus sequence of resilin gene in the mosquito Anopheles gambiae. We demonstrate that An16 is an intrinsically disordered protein that displays unusual dual-phase thermal transition behavior along with responsiveness to pH, ion, light and humidity. Identifying the molecular mechanisms that allow An16 to sense and switch in response to varying environments furthers the ability to design intelligent biomacromolecules.
Subject Biomaterials
Chemical Engineering not elsewhere classified
Keyword(s) An16-resilin
Biomimetic protein
Intrinsically disordered protein (IDP)
Multi-stimuli responsiveness
DOI - identifier 10.1016/j.actbio.2014.07.030
Copyright notice © 2014 Acta Materialia Inc.
ISSN 1742-7061
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