Engineering Stent Based Delivery System for Esophageal Cancer Using Docetaxel

Shaikh, M, Choudhury, N, Knott, R and Garg, S 2015, 'Engineering Stent Based Delivery System for Esophageal Cancer Using Docetaxel', Molecular Pharmaceutics, vol. 12, no. 7, pp. 2305-2317.


Document type: Journal Article
Collection: Journal Articles

Title Engineering Stent Based Delivery System for Esophageal Cancer Using Docetaxel
Author(s) Shaikh, M
Choudhury, N
Knott, R
Garg, S
Year 2015
Journal name Molecular Pharmaceutics
Volume number 12
Issue number 7
Start page 2305
End page 2317
Total pages 13
Publisher American Chemical Society
Abstract Esophageal cancer patients are often diagnosed as "advanced" cases. These patients are subjected to palliative stenting using self-expanding metallic stents (SEMS) to maintain oral alimentation. Unfortunately, SEMS get reoccluded due to tumor growth, in and over the stent struts. To investigate potential solutions to this problem, docetaxel (DTX) delivery films were prepared using PurSil AL 20 (PUS), which can be used as a covering material for the SEMS. Drug polymer miscibility and interactions were studied. Bilayer films were prepared by adhering the blank film to the DTX loaded film in order to maintain the unidirectional delivery to the esophagus. In vitro release and the local DTX delivery were studied using in vitro permeation experiments. It was found that DTX and PUS were physically and chemically compatible. The bilayer films exhibited sustained release (>30 days) and minimal DTX permeation through esophageal tissues in vitro. The rate-determining step for the DTX delivery was calculated. It was found that >0.9 fraction of rate control lies with the esophageal tissues, suggesting that DTX delivery can be sustained for longer periods compared to the in vitro release observed. Thus, the bilayer films can be developed as a localized sustained delivery system in combination with the stent.
Subject Physical Chemistry of Materials
Biomaterials
Composite and Hybrid Materials
Keyword(s) esophageal cancer
drug eluting stent
docetaxel
cancer chemotherapy
polymeric drug delivery system
controlled release
formulation
SAXS analysis
DOI - identifier 10.1021/mp500851u
Copyright notice © 2015 American Chemical Society
ISSN 1543-8384
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