Effect of polymer microstructure on the docetaxel release and stability of polyurethane formulation

Shaikh, M, Choudhury, N, Knott, R, Kanwar, J and Garg, S 2016, 'Effect of polymer microstructure on the docetaxel release and stability of polyurethane formulation', European Journal of Pharmaceutics and Biopharmaceutics, vol. 101, pp. 82-89.


Document type: Journal Article
Collection: Journal Articles

Title Effect of polymer microstructure on the docetaxel release and stability of polyurethane formulation
Author(s) Shaikh, M
Choudhury, N
Knott, R
Kanwar, J
Garg, S
Year 2016
Journal name European Journal of Pharmaceutics and Biopharmaceutics
Volume number 101
Start page 82
End page 89
Total pages 8
Publisher Elsevier
Abstract PurSil (R) AL20 (PUS), a copolymer of 4,4'-dicyclohexylmethane diisocyanate (HMDI), 1,4-butane diol (BD), poly-tetramethylene oxide (PTMO) and poly-dimethyl siloxane (PDMS) was investigated for stability as a vehicle for Docetaxel (DTX) delivery through oesophageal drug eluting stent (DES). On exposure to stability test conditions, it was found that DTX release rate declined at 4 and 40 degrees C. In order to divulge reasons underlying this, changes in DTX solid state as well as PUS microstructure were followed. It was found that re-crystallization of DTX in PDMS rich regions was reducing the drug release at both 4 degrees C and 40 degrees C samples. So far microstructural features have not been correlated with stability and drug release, and in this study we found that at 40 degrees C increase in microstructural domain sizes and the inter-domain distances (from 85 A to 129 A) were responsible for hindering the DTX release in addition to DTX re-crystallization.
Subject Physical Chemistry of Materials
Biomaterials
Composite and Hybrid Materials
Keyword(s) Docetaxel
Drug release
Polymer microstructure
Polyurethane
Small-angle X-ray diffraction
Stability
DOI - identifier 10.1016/j.ejpb.2016.01.015
Copyright notice © 2016 Elsevier B.V. All rights reserved.
ISSN 0939-6411
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