A simple, fast and low-cost turn-on fluorescence method for dopamine detection using in situ reaction

Zhang, X, Zhu, Y, Li, X, Guo, X, Zhang, B, Jia, X and Dai, B 2016, 'A simple, fast and low-cost turn-on fluorescence method for dopamine detection using in situ reaction', Analytica Chimica Acta, vol. 944, pp. 51-56.


Document type: Journal Article
Collection: Journal Articles

Title A simple, fast and low-cost turn-on fluorescence method for dopamine detection using in situ reaction
Author(s) Zhang, X
Zhu, Y
Li, X
Guo, X
Zhang, B
Jia, X
Dai, B
Year 2016
Journal name Analytica Chimica Acta
Volume number 944
Start page 51
End page 56
Total pages 6
Publisher Elsevier
Abstract A simple, fast and low-cost method for dopamine (DA) detection based on turn-on fluorescence using resorcinol is developed. The rapid reaction between resorcinol and DA allows the detection to be performed within 5 min, and the reaction product (azamonardine) with high quantum yield generates strong fluorescence signal for sensitive optical detection. The detection exhibits a high sensitivity to DA with a wide linear range of 10 nM-20 μM and the limit of detection is estimated to be 1.8 nM (S/N = 3). This approach has been successfully applied to determine DA concentrations in human urine samples with satisfactory quantitative recovery of 97.84%-103.50%, which shows great potential in clinical diagnosis.
Subject Analytical Chemistry not elsewhere classified
Keyword(s) Azamonardine
Dopamine detection
Resorcinol
Turn-on fluorescence
DOI - identifier 10.1016/j.aca.2016.09.023
Copyright notice © 2016 Elsevier B.V. All rights reserved.
ISSN 0003-2670
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