Statin resistance in Candida glabrata

Subhan, M, Faryal, R and Macreadie, I 2018, 'Statin resistance in Candida glabrata', Biotechnology Letters, vol. 40, no. 43382, pp. 1389-1394.


Document type: Journal Article
Collection: Journal Articles

Title Statin resistance in Candida glabrata
Author(s) Subhan, M
Faryal, R
Macreadie, I
Year 2018
Journal name Biotechnology Letters
Volume number 40
Issue number 43382
Start page 1389
End page 1394
Total pages 6
Publisher Springer Netherlands
Abstract Objectives: Reduced efficacy of statins has been observed in people but the mechanism of this resistance is unclear and no statin-resistance mutations in the catalytic domain of HMGCR have been reported. The present study focused on looking for statin-resistance mutations and examining the mechanism of statin resistance using Candida glabrata as a model organism. Results: C. glabrata was cultured in media containing lovastatin, simvastatin or atorvastatin to obtain lovastatin-, simvastatin- and atorvastatin-resistant mutants. A single mutant from each was purified for further analysis. In each mutant, gene sequencing showed there were no changes in the catalytic domain of HMGCR. HMGCR was overexpressed in two resistant isolates suggesting that increased production of HMGCR can lead to resistance. In a third mutant, HMGCR activity was unaltered, suggesting a non-HMGCR related mechanism, such as increased drug efflux, could be operating. Conclusions: Candida glabrata is a useful model organism for examining resistance to statins. Further studies are warranted to examine the precise molecular mechanisms of statin resistance.
Subject Gene Expression (incl. Microarray and other genome-wide approaches)
Keyword(s) Candida glabrata
Cholesterol
HMG-CoA reductase
Statin resistance
Yeast
DOI - identifier 10.1007/s10529-018-2597-1
Copyright notice © Springer Nature B.V. 2018
ISSN 0141-5492
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