Using a multi-biomarker approach to assess the effects of pollution on sand flathead (Platycephalus bassensis) from Port Phillip Bay, Victoria, Australia

Fu, D, Bridle, A, Leef, M, Gagnon, M, Hassell, K and Nowak, B 2017, 'Using a multi-biomarker approach to assess the effects of pollution on sand flathead (Platycephalus bassensis) from Port Phillip Bay, Victoria, Australia', Marine Pollution Bulletin, vol. 119, no. 1, pp. 211-219.


Document type: Journal Article
Collection: Journal Articles

Title Using a multi-biomarker approach to assess the effects of pollution on sand flathead (Platycephalus bassensis) from Port Phillip Bay, Victoria, Australia
Author(s) Fu, D
Bridle, A
Leef, M
Gagnon, M
Hassell, K
Nowak, B
Year 2017
Journal name Marine Pollution Bulletin
Volume number 119
Issue number 1
Start page 211
End page 219
Total pages 9
Publisher Elsevier
Abstract Hepatic gene expression and liver histology were examined in sand flathead (Platycephalus bassensis) from six locations in Port Phillip Bay, Victoria, Australia. Four sets of genes including thyroid-related genes (D1, D2, TTR, TRα and TRβ), metal metabolism-related genes (MT, MTF1, TF, Ferritin and FPN1), apoptosis-related genes (Diablo/SMAC1, Diablo/SMAC2 and CYP1A) and an endoplasmic reticulum stress biomarker gene (GRP78) were examined in female flathead using qRT-PCR. TRβ and Diablo/SMAC1 gene expression was significantly up-regulated in fish from all polluted sites compared to those from a reference site. The transcripts of TRα and FPN1 were significantly higher in flathead from Corio Bay, while the hepatic mRNA of TTR and GRP78 were significantly lower in those fish. Positive correlations were observed between Diablo/SMAC1 and CYP1A, D2 and TRβ, TRα and TRβ. This study demonstrates that application of pathway-based biomarker genes and histopathology can provide comprehensive information on the impact of environmental pollutants on fish.
Subject Environmental Monitoring
Keyword(s) Biomarkers
Histology
Gene expression
Sand flathead
Port Phillip Bay
DOI - identifier 10.1016/j.marpolbul.2017.03.067
Copyright notice © 2017 Elsevier Ltd. All rights reserved.
ISSN 0025-326X
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