Dynamic multistimuli-responsive reversible chiral transformation in supramolecular helices

Goskulwad, S, La, D, Al Kobaisi, M, Bhosale, S, Bansal, V, Vinu, A, Ariga, K and Bhosale, S 2018, 'Dynamic multistimuli-responsive reversible chiral transformation in supramolecular helices', Scientific Reports, vol. 8, no. 1, pp. 1-11.


Document type: Journal Article
Collection: Journal Articles

Title Dynamic multistimuli-responsive reversible chiral transformation in supramolecular helices
Author(s) Goskulwad, S
La, D
Al Kobaisi, M
Bhosale, S
Bansal, V
Vinu, A
Ariga, K
Bhosale, S
Year 2018
Journal name Scientific Reports
Volume number 8
Issue number 1
Start page 1
End page 11
Total pages 11
Publisher Nature Publishing Group
Abstract The design of new chiral chromophores that allow tunable assembly of higher order helical structures by using natural stimuli offers promising avenue in understanding various biological processes. In particular, access to dynamic multistimuli-responsive systems can provide real-time monitoring of chiral transformation in chemical and biological systems. We report on the synthesis of naphthalenediimide appended L-glutamate (NDI-L-Glu) that self-assembles into chiral supramolecular structures under physiological conditions. Specifically, NDI-L-Glu shows a mixture of left- and right-handed helices under physiological conditions, and any deviation from the ambient biochemical environment has a remarkable influence on the chirality of these structures. For instance, acidic environments shift the helicity to left-handedness while the alkaline conditions reversed the helical structures to right-handedness, thereby mimicking the molecular virulence mechanism of tobacco mosaic virus (TMV). The chirality of these supramolecular assemblies can also be controllably tuned by using temperature as an external stimulus, allowing reversible flip of helicity.
Subject Nanobiotechnology
DOI - identifier 10.1038/s41598-018-29152-9
Copyright notice © The Author(s) 2018. Creative Commons Attribution 4.0 International License
ISSN 2045-2322
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