Functional Femtoliter Droplets for Ultrafast Nanoextraction and Supersensitive Online Microanalysis

Li, M, Dyett, B, Yu, H, Bansal, V and Zhang, X 2018, 'Functional Femtoliter Droplets for Ultrafast Nanoextraction and Supersensitive Online Microanalysis', Small, vol. 15, no. 1, pp. 1-8.


Document type: Journal Article
Collection: Journal Articles

Title Functional Femtoliter Droplets for Ultrafast Nanoextraction and Supersensitive Online Microanalysis
Author(s) Li, M
Dyett, B
Yu, H
Bansal, V
Zhang, X
Year 2018
Journal name Small
Volume number 15
Issue number 1
Start page 1
End page 8
Total pages 8
Publisher Wiley - V C H Verlag GmbH & Co. KGaA
Abstract A universal femtoliter surface droplet-based platform for direct quantification of trace of hydrophobic compounds in aqueous solutions is presented. Formation and functionalization of femtoliter droplets, concentrating the analyte in the solution, are integrated into a simple fluidic chamber, taking advantage of the long-term stability, large surface-to-volume ratio, and tunable chemical composition of these droplets. In situ quantification of the extracted analytes is achieved by surface-enhanced Raman scattering (SERS) spectroscopy by nanoparticles on the functionalized droplets. Optimized extraction efficiency and SERS enhancement by tuning droplet composition enable quantitative determination of hydrophobic model compounds of rhodamine 6G, methylene blue, and malachite green with the detection limit of 10-9 to 10-11 m and a large linear range of SERS signal from 10-9 to 10-6 m of the analytes. The approach addresses the current challenges of reproducibility and the lifetime of the substrate in SERS measurements. This novel surface droplet platform combines liquid-liquid extraction and highly sensitive and reproducible SERS detection, providing a promising technique in current chemical analysis related to environment monitoring, biomedical diagnosis, and national security monitoring.
Subject Sensor Technology (Chemical aspects)
Keyword(s) microreactors
nanoextraction
on-line analysis
surface droplets
surface-enhanced Raman scattering (SERS)
DOI - identifier 10.1002/smll.201804683
Copyright notice © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
ISSN 1613-6810
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