Neuroprotection strategies for the newborn

Fleiss, B, Thornton, C and Gressens, P 2017, 'Neuroprotection strategies for the newborn' in Christine Gleason, Sandra Juul (ed.) Avery's Diseases of the Newborn, Elsevier, Philadelphia, USA, pp. 1-15.


Document type: Book Chapter
Collection: Book Chapters

Title Neuroprotection strategies for the newborn
Author(s) Fleiss, B
Thornton, C
Gressens, P
Year 2017
Title of book Avery's Diseases of the Newborn
Publisher Elsevier
Place of publication Philadelphia, USA
Editor(s) Christine Gleason, Sandra Juul
Start page 1
End page 15
Subjects Innate Immunity
Neurology and Neuromuscular Diseases
Paediatrics
Summary Perinatal brain injury is the leading cause of death and disability in children. Such damage can be induced by multiple factors, varies in severity between individuals, affects infants of different genetic backgrounds, and occurs at various stages of the physiological developmental program. This complexity creates innumerable difficulties in creating therapeutic agents. A wealth of experimental studies has engaged in the understanding of brain injury pathophysiology and in the development of strategies that may be beneficial for the neurological outcome of infants. Clinical trials have demonstrated the partial neuroprotective effects of hypothermia and magnesium sulfate in human neonates. Trials for the neuroprotective effects of the pluripotent hormone melatonin are ongoing. In the following chapter we review the experimental and clinical data on neuroprotective strategies.
Copyright notice © Saunders 2012
ISBN 9780323401395
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