Brain Edema in Developing Brain Diseases

Moretti, R, Chhor, V, Titomanilo, L, Fleiss, B and Gressens, P 2017, 'Brain Edema in Developing Brain Diseases' in Jerome Badaut, Nikolaus Plesnila (ed.) Brain Edema: From molecular mechanisms to clinical practice, Academic Press, London, United Kingdom, pp. 393-429.


Document type: Book Chapter
Collection: Book Chapters

Title Brain Edema in Developing Brain Diseases
Author(s) Moretti, R
Chhor, V
Titomanilo, L
Fleiss, B
Gressens, P
Year 2017
Title of book Brain Edema: From molecular mechanisms to clinical practice
Publisher Academic Press
Place of publication London, United Kingdom
Editor(s) Jerome Badaut, Nikolaus Plesnila
Start page 393
End page 429
Subjects Neurology and Neuromuscular Diseases
Central Nervous System
Paediatrics
Summary Brain edema was initially defined as an increase in net brain water content leading to an increase in tissue volume. Extensive research has led to a more accurate definition, including pathophysiological characteristics such as molecular, cellular, structural, and functional changes in the bloodbrain barrier (BBB), microcirculation, cell volume regulation, and cell death. With even small changes in cellular and extracellular volume, cerebral edema can compromise regional or global cerebral blood flow and metabolism, or result in the compression of vital structures, given the fixed volume of the rigid skull and the secondary neuronal injury caused by swelling. Less is known about developing brain. Brain water content is higher in juvenile rats than in adults, and edema formation is more severe and extensive in many pediatric neurological disorders. This reviews intent is to try to summarize different factors that are probably implied in these differences.
Copyright notice © 2017 Elsevier Inc. All rights reserved.
Keyword(s) Blood-brain barrier
brain edema
microcirculation
cell volume regulation
cell death
DOI - identifier 10.1016/B978-0-12-803196-4.00021-7
ISBN 9780128031964
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