Protocols to Evaluate Cigarette Smoke-Induced Lung Inflammation and Pathology in Mice

Vlahos, R and Bozinovski, S 2018, 'Protocols to Evaluate Cigarette Smoke-Induced Lung Inflammation and Pathology in Mice' in Brendan J. Jenkins (ed.) Inflammation and Cancer: Methods and Protocols, Springer Nature, New York, United States, pp. 53-63.


Document type: Book Chapter
Collection: Book Chapters

Title Protocols to Evaluate Cigarette Smoke-Induced Lung Inflammation and Pathology in Mice
Author(s) Vlahos, R
Bozinovski, S
Year 2018
Title of book Inflammation and Cancer: Methods and Protocols
Publisher Springer Nature
Place of publication New York, United States
Editor(s) Brendan J. Jenkins
Start page 53
End page 63
Subjects Respiratory Diseases
Summary Cigarette smoking is a major cause of chronic obstructive pulmonary disease (COPD). Inhalation of cigarette smoke causes inflammation of the airways, airway wall remodelling, mucus hypersecretion and progressive airflow limitation. Much of the disease burden and health care utilisation in COPD is associated with the management of its comorbidities and infectious (viral and bacterial) exacerbations (AECOPD). Comorbidities, in particular skeletal muscle wasting, cardiovascular disease and lung cancer markedly impact on disease morbidity, progression and mortality. The mechanisms and mediators underlying COPD and its comorbidities are poorly understood and current COPD therapy is relatively ineffective. Many researchers have used animal modelling systems to explore the mechanisms underlying COPD, AECOPD and comorbidities of COPD with the goal of identifying novel therapeutic targets. Here we describe a mouse model that we have developed to define the cellular, molecular and pathological consequences of cigarette smoke exposure and the development of comorbidities of COPD.
Copyright notice © Springer Science+Business Media, LLC 2018
Keyword(s) COPD
Cigarette smoke
Comorbidities
AECOPD
Emphysema
Lung inflammation
DOI - identifier 10.1007/978-1-4939-7568-6_5
ISBN 9781493975679
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