Dose response and stability of water equivalent PRESAGE® dosimeters for synchrotron radiation therapy dosimetry

Gagliardi, F, Franich, R and Geso, M 2018, 'Dose response and stability of water equivalent PRESAGE® dosimeters for synchrotron radiation therapy dosimetry', Physics in Medicine and Biology, vol. 63, no. 23, pp. 1-9.


Document type: Journal Article
Collection: Journal Articles

Title Dose response and stability of water equivalent PRESAGE® dosimeters for synchrotron radiation therapy dosimetry
Author(s) Gagliardi, F
Franich, R
Geso, M
Year 2018
Journal name Physics in Medicine and Biology
Volume number 63
Issue number 23
Start page 1
End page 9
Total pages 9
Publisher Institute of Physics
Abstract This research investigated the dose response and post-irradiation stability of water-equivalent PRESAGE® dosimeters exposed to synchrotron radiation. Water-equivalent PRESAGE® dosimeters were irradiated up to 1000 Gy in a synchrotron x-ray beam with a mean energy of 95.3 keV. The change in optical density was measured using UV/visible spectrophotometry pre- and post-irradiation using a wavelength of 630 nm. Dose response was found to be approximately linear from 0-200 Gy with saturation occurring above 300 Gy. The post-irradiation stability was determined by measuring the change in optical density at 10, 30, 60, 180, 420 min and 7, 21 and 33 d post-irradiation for three groups of dosimeters stored at different temperatures. Each group had two dosimeters irradiated at 50, 100, 200 and 300 Gy and each group was stored at a different temperature following irradiation: room temperature (22 °C), 4 °C and -18 °C. The optimal time for readout of the dosimeters varied with the post-irradiation storage temperature. The room temperature group had an optimal time-to-readout of 10 min for maximum signal before fading, while the 4 °C group was reasonably stable from 90 min to 1 week. The -18 °C group showed the least amount of ongoing post-irradiation development and fading with an optimal readout window from 30 min to 21 d. The intra-batch variation between the mean of each temperature control group was 4.2% at 10 min post-irradiation.
Subject Synchrotrons; Accelerators; Instruments and Techniques
Keyword(s) PRESAGE® dosimeter
synchrotron radiation therapy
UV/Vis spectrophotometry
DOI - identifier 10.1088/1361-6560/aaf1f5
Copyright notice © 2018 Institute of Physics and Engineering in Medicine
ISSN 0031-9155
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