Effects of dietary fibre from the traditional Indonesian food, green cincau (Premna oblongifolia merr.) on preneoplastic lesions and short chain fatty acid production in an azoxymethane rat model of colon cancer

Nurdin, S, Le Leu, R, Aburto Medina, A, Young, G, Stangoulis, J, Ball, A and Abbott, C 2018, 'Effects of dietary fibre from the traditional Indonesian food, green cincau (Premna oblongifolia merr.) on preneoplastic lesions and short chain fatty acid production in an azoxymethane rat model of colon cancer', International Journal of Molecular Sciences, vol. 19, no. 9, pp. 1-18.


Document type: Journal Article
Collection: Journal Articles

Title Effects of dietary fibre from the traditional Indonesian food, green cincau (Premna oblongifolia merr.) on preneoplastic lesions and short chain fatty acid production in an azoxymethane rat model of colon cancer
Author(s) Nurdin, S
Le Leu, R
Aburto Medina, A
Young, G
Stangoulis, J
Ball, A
Abbott, C
Year 2018
Journal name International Journal of Molecular Sciences
Volume number 19
Issue number 9
Start page 1
End page 18
Total pages 18
Publisher M D P I AG
Abstract Green cincau (Premna oblongifolia Merr.) is a traditional food of Indonesia and provides a natural source of dietary fibre and antioxidants. This study evaluated the ability of green cincau, and other dietary fibres with or without the addition of anti-oxidant, epigallocatechin-3-gallate (EGCG), to prevent colorectal cancer in a 12 week azoxymethane (AOM) rat model. While all dietary treatments stimulated short chain fatty acid production (SCFA) in the digesta and faeces, no one treatment was able to significantly protect against aberrant crypt formation (ACF), when compared to the control diet. However, feeding green cincau leaves or extracts did not result in an increase in ACF compared to the control diet. Unexpectedly, when the dietary fibre source was pectin, 0.1% EGCG increased proliferative activity and liver lipid peroxidation when compared to the control diet containing cellulose. Examination of faecal microbial communities identified the presence of short chain acid producing bacteria, but a distinct community profile was not observed from any individual diet group. Overall, this research implies that combining dietary fibre with an antioxidant does not automatically equate to a beneficial response. Further work is required to investigate the health-promoting properties of green cincau.
Subject Microbial Ecology
Keyword(s) Aberrant crypt foci
Antioxidant
Azoxymethane
Colorectal cancer
Dietary fibre
Green cincau
Gut microbiota
Short chain fatty acids
DOI - identifier 10.3390/ijms19092593
Copyright notice © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
ISSN 1661-6596
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