A Critical Review of Models of Perinatal Infection

Dean, J, Shi, Z, Fleiss, B, et al, , Groenendaal, F, van Bel, F, Derrick, M, Juul, S, Tan, S, Gressens, P, Mallard, C, Bennet, L and Gunn, A 2015, 'A Critical Review of Models of Perinatal Infection', Developmental Neuroscience, vol. 37, no. 45, pp. 289-304.


Document type: Journal Article
Collection: Journal Articles

Title A Critical Review of Models of Perinatal Infection
Author(s) Dean, J
Shi, Z
Fleiss, B
et al,
Groenendaal, F
van Bel, F
Derrick, M
Juul, S
Tan, S
Gressens, P
Mallard, C
Bennet, L
Gunn, A
Year 2015
Journal name Developmental Neuroscience
Volume number 37
Issue number 45
Start page 289
End page 304
Total pages 16
Publisher S. Karger AG
Abstract One of the central, unanswered questions in perinatology is why preterm infants continue to have such poor long-term neurodevelopmental, cognitive and learning outcomes, even though severe brain injury is now rare. There is now strong clinical evidence that one factor underlying disability may be infection, as well as nonspecific inflammation, during fetal and early postnatal life. In this review, we examine the experimental evidence linking both acute and chronic infection/inflammation with perinatal brain injury and consider key experimental determinants, including the microglia response, relative brain and immune maturity and the pattern of exposure to infection. We highlight the importance of the origin and derivation of the bacterial cell wall component lipopolysaccharide. Such experimental paradigms are essential to determine the precise time course of the inflammatory reaction and to design targeted neuroprotective strategies to protect the perinatal brain from infection and inflammation.
Subject Innate Immunity
Neurology and Neuromuscular Diseases
Paediatrics
Keyword(s) Fetal sheep
Lipopolysaccharide
Postnatal infection
Prenatal infection
Rodents
White matter injury
DOI - identifier 10.1159/000370309
Copyright notice © 2015 S. Karger AG, Basel.
ISSN 0378-5866
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