Single step formation of biocompatible bimetallic alloy nanoparticles of gold and silver using isonicotinylhydrazide

Navya, P, Madhyastha, H, Madhyastha, R, Nakajima, Y, Maruyama, M, Srinivas, S, Jain, D, Amin, M, Bhargava, S and Daima, H 2019, 'Single step formation of biocompatible bimetallic alloy nanoparticles of gold and silver using isonicotinylhydrazide', Materials Science and Engineering C, vol. 96, pp. 286-294.


Document type: Journal Article
Collection: Journal Articles

Title Single step formation of biocompatible bimetallic alloy nanoparticles of gold and silver using isonicotinylhydrazide
Author(s) Navya, P
Madhyastha, H
Madhyastha, R
Nakajima, Y
Maruyama, M
Srinivas, S
Jain, D
Amin, M
Bhargava, S
Daima, H
Year 2019
Journal name Materials Science and Engineering C
Volume number 96
Start page 286
End page 294
Total pages 9
Publisher Elsevier
Abstract Manufacturing nanoparticles with controlled physicochemical properties using environment-friendly routes have potential to open new prospects for a variety of applications. Accordingly, several approaches have been established for manufacturing metal nanoparticles. Many of these approaches entail the use of hazardous chemicals and could be toxic to the environment, and cannot be used readily for biomedical applications. In the present work, we report a single step bio-friendly approach to formulate gold (Au), silver (Ag), and Au-Ag alloy nanoparticles with desired surface corona and composition using isonicotinylhydrazide (INH) as a reducing agent. INH also functioned as a stabilizing agent by enabling a surface corona around the nanoparticles. Remarkably, within a single step INH could also provide a handle in regulating the composition of Au and Ag in bimetallic systems without any additional chemical modification. The physicochemical and surface properties of the different nanoparticles thus obtained have been examined by analytical, spectroscopic and microscopic techniques. Cell cytotoxicity (release of lactate dehydrogenase), cell viability and intracellular reactive oxygen species (ROS) assays confirmed that the Au, Ag, and Au-Ag bimetallic nanoparticles prepared with INH are biocompatible. Finally, the presence of organic surface corona of INH on the nanoparticles was found to impart nanozyme activity and antimycobacterial sensitivity to the nanoparticles.
Subject Synthesis of Materials
Nanomaterials
Nanomedicine
Keyword(s) Antimycobacterial
Biocompatible
Gold-silver nanoparticles
Isonicotinylhydrazide
Nanozyme
Physicochemical
DOI - identifier 10.1016/j.msec.2018.11.024
Copyright notice © 2018 Elsevier B.V.
ISSN 0928-4931
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