Identification and Directed Development of Non-Organic Catalysts with Apparent Pan-Enzymatic Mimicry into Nanozymes for Efficient Prodrug Conversion

Walther, R, Winther, A, Fruergaard, A, Van Den Akker, W, Singh, M and Bansal, V., et al, 2019, 'Identification and Directed Development of Non-Organic Catalysts with Apparent Pan-Enzymatic Mimicry into Nanozymes for Efficient Prodrug Conversion', Angewandte Chemie - International Edition, vol. 58, no. 1, pp. 278-282.


Document type: Journal Article
Collection: Journal Articles

Title Identification and Directed Development of Non-Organic Catalysts with Apparent Pan-Enzymatic Mimicry into Nanozymes for Efficient Prodrug Conversion
Author(s) Walther, R
Winther, A
Fruergaard, A
Van Den Akker, W
Singh, M
Bansal, V., et al,
Year 2019
Journal name Angewandte Chemie - International Edition
Volume number 58
Issue number 1
Start page 278
End page 282
Total pages 5
Publisher Wiley
Abstract Nanozymes, nanoparticles that mimic the natural activity of enzymes, are intriguing academically and are important in the context of the Origin of Life. However, current nanozymes offer mimicry of a narrow range of mammalian enzymes, near-exclusively performing redox reactions. We present an unexpected discovery of non-proteinaceous enzymes based on metals, metal oxides, 1D/2D-materials, and non-metallic nanomaterials. The specific novelty of these findings lies in the identification of nanozymes with apparent mimicry of diverse mammalian enzymes, including unique pan-glycosidases. Further novelty lies in the identification of the substrate scope for the lead candidates, specifically in the context of bioconversion of glucuronides, that is, human metabolites and privileged prodrugs in the field of enzyme-prodrug therapies. Lastly, nanozymes are employed for conversion of glucuronide prodrugs into marketed anti-inflammatory and antibacterial agents, as well as "nanozyme prodrug therapy" to mediate antibacterial measures.
Subject Nanobiotechnology
Keyword(s) enzyme mimicry
enzyme-prodrug therapy
glucuronide
nanozymes
prodrugs
DOI - identifier 10.1002/anie.201812668
Copyright notice © 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
ISSN 1433-7851
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