Expansion of the Clostridium perfringens toxin-based typing scheme

Rood, J, Adams, V, Lacey, J and Moore, R., et al., 2018, 'Expansion of the Clostridium perfringens toxin-based typing scheme', Anaerobe, vol. 53, pp. 5-10.


Document type: Journal Article
Collection: Journal Articles

Title Expansion of the Clostridium perfringens toxin-based typing scheme
Author(s) Rood, J
Adams, V
Lacey, J
Moore, R., et al.,
Year 2018
Journal name Anaerobe
Volume number 53
Start page 5
End page 10
Total pages 6
Publisher Academic Press
Abstract Clostridium perfringens causes many different histotoxic and enterotoxic diseases in humans and animals as a result of its ability to produce potent protein toxins, many of which are extracellular. The current scheme for the classification of isolates was finalized in the 19605 and is based on their ability to produce a combination of four typing toxins - alpha-toxin, (beta-toxin, epsilon-toxin and t-toxin to divide C perfringens strains into toxinotypes A to E. However, this scheme is now outdated since it does not take into account the discovery of other toxins that have been shown to be required for specific C. perfringens-mediated diseases. We present a long overdue revision of this toxinotyping scheme. The principles for the expansion of the typing system are described, as is a mechanism by which new toxinotypes can be proposed and subsequently approved. Based on these criteria two new toxinotypes have been established. C perfringens type F consists of isolates that produce C. perfringens enterotoxin (CPE), but not beta-toxin, epsilon-toxin or t-toxin. Type F strains will include strains responsible for C. perfringens-mediated human food poisoning and antibiotic associated diarrhea. C. perfringens type G comprises isolates that produce NetB toxin and thereby cause necrotic enteritis in chickens. There are at least two candidates for future C. perfringens toxinotypes, but further experimental work is required before these toxinotypes can formally be proposed and accepted.
Subject Bacteriology
Keyword(s) Clostridium perfringens
Disease
Pathogenesis
Terminology
Toxinotyping
Toxins
DOI - identifier 10.1016/j.anaerobe.2018.04.011
Copyright notice © 2018 Elsevier Ltd. All rights reserved.
ISSN 1075-9964
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