Elastomeric microvalve geometry affects haemocompatibility

Szydzik, C, Brazilek, R, Khoshmanesh, K, Akbaridoust, F, Knoerzer, M, Thurgood, P, Muir, I, Marusic, I, Nandurkar, H, Mitchell, A and Nesbitt, W 2018, 'Elastomeric microvalve geometry affects haemocompatibility', Lab on a Chip, vol. 18, no. 12, pp. 1778-1792.

Document type: Journal Article
Collection: Journal Articles

Title Elastomeric microvalve geometry affects haemocompatibility
Author(s) Szydzik, C
Brazilek, R
Khoshmanesh, K
Akbaridoust, F
Knoerzer, M
Thurgood, P
Muir, I
Marusic, I
Nandurkar, H
Mitchell, A
Nesbitt, W
Year 2018
Journal name Lab on a Chip
Volume number 18
Issue number 12
Start page 1778
End page 1792
Total pages 15
Publisher Royal Society of Chemistry
Abstract This paper reports on the parameters that determine the haemocompatibility of elastomeric microvalves for blood handling in microfluidic systems. Using a comprehensive investigation of blood function, we describe a hierarchy of haemocompatibility as a function of microvalve geometry and identify a "normally-closed" v-gate pneumatic microvalve design that minimally affects blood plasma fibrinogen and von Willebrand factor composition, minimises effects on erythrocyte structure and function, and limits effects on platelet activation and aggregation, while facilitating rapid switching control for blood sample delivery. We propose that the haemodynamic profile of valve gate geometries is a significant determinant of platelet-dependent biofouling and haemocompatibility. Overall our findings suggest that modification of microvalve gate geometry and consequently haemodynamic profile can improve haemocompatibility, while minimising the requirement for chemical or protein modification of microfluidic surfaces. This biological insight and approach may be harnessed to inform future haemocompatible microfluidic valve and component design, and is an advance towards lab-on-chip automation for blood based diagnostic systems.
Subject Biomechanical Engineering
Biomedical Engineering not elsewhere classified
DOI - identifier 10.1039/c7lc01320e
Copyright notice © The Royal Society of Chemistry 2018
ISSN 1473-0197
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