BioStructMap: a Python tool for integration of protein structure and sequence-based features

Guy, A, Irani, V, Richards, J and Ramsland, P 2018, 'BioStructMap: a Python tool for integration of protein structure and sequence-based features', Bioinformatics, vol. 34, no. 22, pp. 3942-3944.


Document type: Journal Article
Collection: Journal Articles

Title BioStructMap: a Python tool for integration of protein structure and sequence-based features
Author(s) Guy, A
Irani, V
Richards, J
Ramsland, P
Year 2018
Journal name Bioinformatics
Volume number 34
Issue number 22
Start page 3942
End page 3944
Total pages 3
Publisher Oxford University Press
Abstract A sliding window analysis over a protein or genomic sequence is commonly performed, and we present a Python tool, BioStructMap, that extends this concept to three-dimensional (3D) space, allowing the application of a 3D sliding window analysis over a protein structure. BioStructMap is easily extensible, allowing the user to apply custom functions to spatially aggregated data. BioStructMap also allows mapping of underlying genomic sequences to protein structures, allowing the user to perform genetic-based analysis over spatially linked codonsthis has applications when selection pressures arise at the level of protein structure.
Subject Bioinformatics
Structural Biology (incl. Macromolecular Modelling)
DOI - identifier 10.1093/bioinformatics/bty474
Copyright notice © The Author(s) 2018.
ISSN 1367-4803
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