Metal-dependent inhibition of amyloid fibril formation: synergistic effects of cobalt-tannic acid networks

Zhang, W, Christofferson, A, Besford, Q, Richardson, J, Guo, J, Ju, Y, Kempe, K, Yarovsky, I and Caruso, F 2019, 'Metal-dependent inhibition of amyloid fibril formation: synergistic effects of cobalt-tannic acid networks', Nanoscale, vol. 11, pp. 1921-1928.


Document type: Journal Article
Collection: Journal Articles

Title Metal-dependent inhibition of amyloid fibril formation: synergistic effects of cobalt-tannic acid networks
Author(s) Zhang, W
Christofferson, A
Besford, Q
Richardson, J
Guo, J
Ju, Y
Kempe, K
Yarovsky, I
Caruso, F
Year 2019
Journal name Nanoscale
Volume number 11
Start page 1921
End page 1928
Total pages 8
Publisher Royal Society of Chemistry
Abstract Metal-phenolic networks (MPNs) have received widespread interest owing to their modular incorporation of functional metal ions and phenolic ligands. However, the interaction between MPNs and biomolecules is still relatively unexplored. Herein, we studied the effects of MPN-coated gold nanoparticles on amyloid fibril formation (which is associated with Alzheimer's disease) as a function of the metal ion in the MPN systems. All coated particles examined inhibited amyloid formation, with cobalt(ii) MPN-coated particles exhibiting the highest inhibition activity (90%). Molecular dynamics simulations and quantum mechanics calculations suggested that the geometry of the exposed cobalt coordination site in the cobalt-tannic acid networks facilitates its interactions with histidine and methionine residues in the amyloid beta peptides. Furthermore, the unique structure of cobalt MPNs may enable a wider variety of biomedical applications.
Subject Theoretical and Computational Chemistry not elsewhere classified
DOI - identifier 10.1039/C8NR09221D
Copyright notice © The Royal Society of Chemistry 2019
ISSN 2040-3364
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