Acylated ghrelin suppresses the cytokine response to lipopolysaccharide and does so independently of the hypothalamic-pituitary-adrenal axis

Ziko, I, Sominsky, L, De Luca, S, Lelngei, F and Spencer, S 2018, 'Acylated ghrelin suppresses the cytokine response to lipopolysaccharide and does so independently of the hypothalamic-pituitary-adrenal axis', Brain, Behavior, and Immunity, vol. 74, pp. 86-95.


Document type: Journal Article
Collection: Journal Articles

Title Acylated ghrelin suppresses the cytokine response to lipopolysaccharide and does so independently of the hypothalamic-pituitary-adrenal axis
Author(s) Ziko, I
Sominsky, L
De Luca, S
Lelngei, F
Spencer, S
Year 2018
Journal name Brain, Behavior, and Immunity
Volume number 74
Start page 86
End page 95
Total pages 10
Publisher Academic Press
Abstract Ghrelin, one of the major metabolic hormones involved in controlling energy balance, has recently been shown to have other properties including regulating the hypothalamic-pituitary-adrenal (HPA) axis response to psychological stress and being a potent anti-inflammatory agent. Ghrelin's HPA axis and anti-inflammatory actions have previously been identified as principally due to the acylated form (AG). However, our recent work has also suggested a role for des-acylated ghrelin (DAG) in these functions. Here we hypothesized ghrelin's anti-inflammatory activity is mediated by the HPA axis and this effect is differentially executed by AG and DAG. We gave adult male Wistar rats a concomitant injection of AG or DAG and lipopolysaccharide (LPS) and measured their effects on circulating cytokines, stress hormones and neuronal activation of the paraventricular nucleus of the hypothalamus (PVN). AG, but not DAG significantly suppressed the pro- and anti-inflammatory cytokine response induced by LPS in vivo. DAG also had no effects on any components of the HPA axis. AG, despite stimulating neuronal activation in the PVN in vivo and stimulating ACTH release from the pituitary in vitro, did not affect the HPA axis response to LPS. These findings suggest AG's anti-inflammatory effects are independent of its actions on the HPA axis and have implications for the potential use of this peptide for treatment of inflammatory conditions without compromising HPA axis activity.
Subject Central Nervous System
Keyword(s) Acyl ghrelin
Cytokines
Des-acylated ghrelin
HPA axis
DOI - identifier 10.1016/j.bbi.2018.07.011
Copyright notice © 2018 Elsevier Inc. All rights reserved.
ISSN 0889-1591
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