Blood-Catalyzed RAFT Polymerization

Reyhani, A, Nothling, M, Ranji-Burachaloo, H, McKenzie, T, Fu, Q, Tan, S, Bryant, G and Qiao, G 2018, 'Blood-Catalyzed RAFT Polymerization', Angewandte Chemie - International Edition, vol. 57, no. 32, pp. 10288-10292.


Document type: Journal Article
Collection: Journal Articles

Title Blood-Catalyzed RAFT Polymerization
Author(s) Reyhani, A
Nothling, M
Ranji-Burachaloo, H
McKenzie, T
Fu, Q
Tan, S
Bryant, G
Qiao, G
Year 2018
Journal name Angewandte Chemie - International Edition
Volume number 57
Issue number 32
Start page 10288
End page 10292
Total pages 5
Publisher Wiley - V C H Verlag GmbH and Co. KGaA
Abstract The use of hemoglobin (Hb) contained within red blood cells to drive a controlled radical polymerization via a reversible addition-fragmentation chain transfer (RAFT) process is reported for the first time. No pre-treatment of the Hb or cells was required prior to their use as polymerization catalysts, indicating the potential for synthetic engineering in complex biological microenvironments without the need for ex vivo techniques. Owing to the naturally occurring prevalence of the reagents employed in the catalytic system (Hb and hydrogen peroxide), this approach may facilitate the development of new strategies for in vivo cell engineering with synthetic macromolecules.
Subject Soft Condensed Matter
Polymerisation Mechanisms
Nanochemistry and Supramolecular Chemistry
Keyword(s) hemoglobin
polymerization
RAFT
red blood cells
DOI - identifier 10.1002/anie.201802544
Copyright notice © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
ISSN 1433-7851
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