Labelling proteins and peptides with phosphorescent d6 transition metal complexes

Connell, T and Donnelly, P 2017, 'Labelling proteins and peptides with phosphorescent d6 transition metal complexes', Coordination Chemistry Reviews, vol. 375, pp. 267-284.


Document type: Journal Article
Collection: Journal Articles

Title Labelling proteins and peptides with phosphorescent d6 transition metal complexes
Author(s) Connell, T
Donnelly, P
Year 2017
Journal name Coordination Chemistry Reviews
Volume number 375
Start page 267
End page 284
Total pages 18
Publisher Elsevier
Abstract The phosphorescent properties of Ru(II), Re(I) and Ir(III) transition metal complexes, each with a nominal d 6 electron configuration, are well suited to label peptides and proteins to allow biological imaging by luminescent microscopy. This review focuses on the development of chemistry that enables the ready incorporation of a wide range of phosphorescent metal complexes into peptides or proteins. Different strategies for labelling proteins are presented including the direct coordination of amino acid functional groups to the metal ion, metal complexes where one or more of the ligands coordinated to the metal ion contain reactive functional groups for conjugation to peptides or proteins, and metal complexes designed for site selective bioorthogonal conjugation. Phosphorescent metal complexes that bind and interact with proteins in a non-covalent fashion are also discussed as is the use of metal complexes as single-electron transfer photo-catalysts for the fluorescent labelling of proteins.
Subject Inorganic Chemistry not elsewhere classified
Physical Chemistry not elsewhere classified
Chemical Sciences not elsewhere classified
Keyword(s) Polypyridine Dibenzocyclooctyne Complexes
Necrosis-Factor-Alpha
Luminescent Iridium(Iii) Complexes
Nf-Kappa-B
Bioorthogonal Probes
Living Cells
Rhenium(I) Complexes
Anticancer Activity
Diimine Complexes
Mass Spectrometry
DOI - identifier 10.1016/j.ccr.2017.12.001
Copyright notice © Elsevier B.V. All rights reserved.
ISSN 0010-8545
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