Design, Fabrication and Validation of a Precursor Pulsed Electromagnetic Field Device for Bone Fracture Repair

Daish, C, Blanchard, R, Duchi, S, Onofrillo, C, Augustine, C, Fox, K, Pivonka, P and Pirogova, E 2018, 'Design, Fabrication and Validation of a Precursor Pulsed Electromagnetic Field Device for Bone Fracture Repair', in Proceedings of the 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2018), Honolulu, United States, 18-21 July 2018, pp. 4166-4169.


Document type: Conference Paper
Collection: Conference Papers

Title Design, Fabrication and Validation of a Precursor Pulsed Electromagnetic Field Device for Bone Fracture Repair
Author(s) Daish, C
Blanchard, R
Duchi, S
Onofrillo, C
Augustine, C
Fox, K
Pivonka, P
Pirogova, E
Year 2018
Conference name EMBC 2018
Conference location Honolulu, United States
Conference dates 18-21 July 2018
Proceedings title Proceedings of the 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2018)
Publisher IEEE
Place of publication Danvers, United States
Start page 4166
End page 4169
Total pages 4
Abstract Pulsed electromagnetic field (PEMF) stimulation has been utilized in the medical field since the early 20th century. A number of therapeutic devices have been developed for the treatment of bone fractures and other medical applications. Most of these devices are backed by limited quantitative evidence. In this paper we present the development of a PEMF device for the purposes of determining, through in vitro experimentation, the exposure parameters required to give the most optimal fracture repair. Following electromagnetic field characterization, the device was shown to match well with computational field simulations. The exposure system has been validated through adipose-derived stem cell viability studies with an exposure frequency of 5 Hz and an intensity of 1.1 mT, for a duration of seven days at 30 minutes per day. Under the specific field characteristics chosen, the fatty-tissue derived stem cell proliferation was not hindered and in fact was stimulated ( 0. 025 < P < 0.01) by the PEMF exposure. With continued experimentation of numerous exposure conditions at the cellular scale, it will be possible to quantitatively determine the optimal exposure conditions required to produce the most rapid fresh fracture repair. Following this, there is significant potential for development of an optimized wearable device suitable for enhancing repair of all types of bone fractures.
Subjects Medical Devices
Rehabilitation Engineering
Keyword(s) Pulsed Electromagnetic Fields
Stem cells
Proliferation
Computational modeling
DOI - identifier 10.1109/EMBC.2018.8513239
Copyright notice © 2018 IEEE
ISBN 9781509051571
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