The subcellular distribution of defluorination activity in marsupial and rodent species

Tu, L, Rix, C, Wright, P and Ahokas, J 2004, 'The subcellular distribution of defluorination activity in marsupial and rodent species', Australasian Journal of Ecotoxicology, vol. 10, no. 1, pp. 57-63.


Document type: Journal Article
Collection: Journal Articles

Title The subcellular distribution of defluorination activity in marsupial and rodent species
Author(s) Tu, L
Rix, C
Wright, P
Ahokas, J
Year 2004
Journal name Australasian Journal of Ecotoxicology
Volume number 10
Issue number 1
Start page 57
End page 63
Total pages 7
Publisher Australasian Society for Ecotoxicology
Abstract Defluorination activity in liver subcellular fractions was investigated in species of rodent, marsupials and monotremes. The defluorination activity in the mouse and rat was compared with that of two Australian marsupials, the brushtail possum and tamar wallaby to dtermine the species related differences in fluoroacetate sensitivity. The results indicated that there are clear species differences in the subcellular distribution of defluorination activity in all species, the marsupials possessed a certain amount of defluorination ability in their mitochondrial fractions. The nuclear fractions generally contained a consistent amount of defluorination activity across the four species, indicating the need for further investigation. The single playpus and echidna samples also exhibited a similar distribution of defluorination activity in the liver subcellular fractions. These results clearly localise the fluoroacetate defluorination activity in liver cytosol and provide further insight into the fluoroacetate detoxication ability of Austrlian marsupials and montoremes. The enzyme kinetic study revealed that the Australian marsupials living outside the range of fluoroacetate-containing plants appear to have a lower ability to detoxify fluoroacetate than rodents have. This suggests that marsupials may be more disadvantaged in there metabolic detoxication of some xenobiotics than previously thought.
Subject Environmental Sciences not elsewhere classified
Keyword(s) Fluoracetate
subcellular fraction
defluorination activity
Australian marsupial
Copyright notice c2004 Australasian Society for Ecotoxicology
ISSN 1323-3475
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