The role of lactic acid production by probiotic Lactobacillus species in vaginal health

Tachedjian, G, Aldunate, M, Bradshaw, C and Cone, R 2017, 'The role of lactic acid production by probiotic Lactobacillus species in vaginal health', Research in Microbiology, vol. 168, no. 910, pp. 782-792.


Document type: Journal Article
Collection: Journal Articles

Title The role of lactic acid production by probiotic Lactobacillus species in vaginal health
Author(s) Tachedjian, G
Aldunate, M
Bradshaw, C
Cone, R
Year 2017
Journal name Research in Microbiology
Volume number 168
Issue number 910
Start page 782
End page 792
Total pages 11
Publisher Elsevier
Abstract Vaginal eubiosis is characterised by beneficial lactobacillus-dominated microbiota. In contrast, vaginal dysbiosis (e.g. bacterial vaginosis, BV), characterised by an overgrowth of multiple anaerobes, is associated with an increased risk of adverse urogenital and reproductive health outcomes. A major distinguishing feature between the vaginal environment in states of eubiosis and dysbiosis is a high concentration of lactic acid, produced by lactobacilli, that acidifies the vagina in eubiosis versus a sharp drop in lactic acid and an increase in pH in dysbiosis. Here we review the antimicrobial, antiviral and immunomodulatory properties of lactic acid and the use of lactic acid and lactobacilli probiotics in preventing or treating BV.
Subject Microbiology not elsewhere classified
Medical Microbiology not elsewhere classified
Keyword(s) Lactic acid
Lactobacilli
Metabolites
Microbiota
Probiotics
Vagina
DOI - identifier 10.1016/j.resmic.2017.04.001
Copyright notice © 2017 The Authors, open access article under the Creative Commons CC BY 4.0 license
ISSN 0923-2508
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