The Effects of Experimental Sleep Fragmentation and Sleep Deprivation on the Response of the Genioglossus Muscle to Inspiratory Resistive Loads

Cori, J, Nicholas, C, Avraam, J, Lee, V, Schembri, R, Jackson, M and Jordan, A 2018, 'The Effects of Experimental Sleep Fragmentation and Sleep Deprivation on the Response of the Genioglossus Muscle to Inspiratory Resistive Loads', Journal of Clinical Sleep Medicine, vol. 14, no. 5, pp. 715-724.


Document type: Journal Article
Collection: Journal Articles

Title The Effects of Experimental Sleep Fragmentation and Sleep Deprivation on the Response of the Genioglossus Muscle to Inspiratory Resistive Loads
Author(s) Cori, J
Nicholas, C
Avraam, J
Lee, V
Schembri, R
Jackson, M
Jordan, A
Year 2018
Journal name Journal of Clinical Sleep Medicine
Volume number 14
Issue number 5
Start page 715
End page 724
Total pages 10
Publisher American Academy of Sleep Medicine
Abstract Study Objectives: Poor upper airway dilator muscle function may contribute to obstructive sleep apnea (OSA). Sleep deprivation reduces dilator muscle responsiveness, but sleep fragmentation, which is most characteristic of OSA, has not been assessed. This study compared the effects of sleep deprivation and fragmentation on dilator muscle responsiveness during wakefulness. Methods: Twenty-four healthy individuals (10 female) participated in two consecutive overnight polysomnography (PSG) sessions. The frst was an adaptation PSG of normal sleep. The second was an experimental PSG, where participants were allocated to groups of either normal sleep, no sleep, or fragmented sleep. Inspiratory resistive loading assessment occurred the morning following each PSG. Four 10 cmH2O and four 20 cmH2O loads were presented in random order for 60 seconds while participants were awake and supine. Sleep (electroencephalogram, electrooculogram, electromyogram [EMG]), intramuscular genioglossus activity (EMGGG), and ventilation were measured throughout the loading sessions. Results: Five controls, seven sleep deprivation participants, and seven sleep fragmentation participants provided data. Contrary to expectations, neither EMGGG nor ventilation showed signifcant interaction effects (group × session × load) during resistive loading. There was a main effect of load, with peak EMGGG (mean % max ± standard error) signifcantly higher for the 20 cmH2O load (4.1 ± 0.6) than the 10 cmH 2 O load (3.3 ± 0.6) across both sessions and all groups. Similar results were observed for peak inspiratory flow, duty cycle, and mask pressure. Conclusions: Upper airway function was not affected by 1 night of no sleep or poor-quality sleep. This raises doubt as to whether fragmented sleep in OSA increases disorder severity via reduced upper airway dilator responses.
Subject Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology)
Keyword(s) Airway dilator muscles
Genioglossus
Obstructive sleep apnea
Sleep deprivation
Sleep fragmentation
Ventilation
DOI - identifier 10.5664/jcsm.7090
Copyright notice Copyright © Clearance Center, Inc. Danvers, MA 01923
ISSN 1550-9389
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