Photocatalytic and Chemoselective Transfer Hydrogenation of Diarylimines in Batch and Continuous Flow

van As, D, Connell, T, Brzozowski, M, Scully, A and Polyzos, A 2018, 'Photocatalytic and Chemoselective Transfer Hydrogenation of Diarylimines in Batch and Continuous Flow', Organic Letters, vol. 20, no. 4, pp. 905-908.


Document type: Journal Article
Collection: Journal Articles

Title Photocatalytic and Chemoselective Transfer Hydrogenation of Diarylimines in Batch and Continuous Flow
Author(s) van As, D
Connell, T
Brzozowski, M
Scully, A
Polyzos, A
Year 2018
Journal name Organic Letters
Volume number 20
Issue number 4
Start page 905
End page 908
Total pages 4
Publisher American Chemical Society
Abstract A visible-light photocalytic method for the chemoselective transfer hydrogenation of imines in batch and continuous flow is described. The reaction utilizes Et3N as both hydrogen source and single-electron donor, enabling the selective reduction of imines derived from diarylketimines containing other reducible functional groups including nitriles, halides, esters, and ketones. The dual role of Et3N was confirmed by fluorescence quenching measurements, transient absorption spectroscopy, and deuterium-labeling studies. Continuous-flow processing facilitates straightforward scale-up of the reaction.
Subject Chemical Sciences not elsewhere classified
DOI - identifier 10.1021/acs.orglett.7b03565
Copyright notice © 2018 American Chemical Society
ISSN 1523-7060
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