Amyloid burden and incident depressive symptoms in preclinical Alzheimer's disease

Perin, S, Harrington, K, Lim, Y and Ellis; Kathryn C., et al, 2018, 'Amyloid burden and incident depressive symptoms in preclinical Alzheimer's disease', Journal of Affective Disorders, vol. 229, pp. 269-274.


Document type: Journal Article
Collection: Journal Articles

Title Amyloid burden and incident depressive symptoms in preclinical Alzheimer's disease
Author(s) Perin, S
Harrington, K
Lim, Y
Ellis; Kathryn C., et al,
Year 2018
Journal name Journal of Affective Disorders
Volume number 229
Start page 269
End page 274
Total pages 6
Publisher Elsevier
Abstract Background: Relationships between depression and Alzheimer's disease (AD) may become clearer if studied in preclinical AD where dementia is not present. Method: The aim of this study was to evaluate prospectively, relationships between brain amyloid-beta (A beta), depressive symptoms and screen positive depression in cognitively normal (CN) older adults. Depressive symptoms were measured with the Geriatric Depression Inventory (GDS-15) in CN adults from the Australian Imaging Biomarkers and Lifestyle (AIBL) study without depression at baseline and classified as having abnormally high (A beta+; n = 136) or low (A beta-; n = 449) A beta according to positron emission tomography at 18-month intervals over 72 months. Results: Incident cases of screen positive depression were not increased in A beta+CN adults although small increases in overall depressive symptoms severity (d = - 0.25; 95% CI, - 0.45, - 0.05) and apathy-anxiety symptoms (d = - 0.28; 95% CI - 0.48, - 0.08) were. Limitations: As the AIBL sample is an experimental sample, no individuals had severe medical illnesses or significant psychiatric disorders. Additionally, individuals who had evidence of screen-positive depression at screening were excluded from enrolment in the AIBL study. Thus, the current data can be considered only as providing a foundation for understanding relationships between A beta and depression in preclinical AD. Conclusions: These results suggest that the presence of a depressive disorder or even increased depressive symptoms are themselves unlikely to be a direct consequence of increasing A beta. New depressive disorders presenting in CN older adults could therefore be investigated for aetiologies beyond AD.
Subject Medical and Health Sciences not elsewhere classified
Keyword(s) Depression
Amyloid-beta
Alzheimer's disease
DOI - identifier 10.1016/j.jad.2017.12.101
Copyright notice © Elsevier B.V. All rights reserved.
ISSN 0165-0327
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