Active bioparticle manipulation in microfluidic systems

Ali, M, Ostrikov, K, Khalid, F, Majlis, B and Kayani, A 2016, 'Active bioparticle manipulation in microfluidic systems', RSC Advances, vol. 6, no. 114, pp. 113066-113094.

Document type: Journal Article
Collection: Journal Articles

Title Active bioparticle manipulation in microfluidic systems
Author(s) Ali, M
Ostrikov, K
Khalid, F
Majlis, B
Kayani, A
Year 2016
Journal name RSC Advances
Volume number 6
Issue number 114
Start page 113066
End page 113094
Total pages 29
Publisher Royal Society of Chemistry
Abstract The motion of bioparticles in a microfluidic environment can be actively controlled using several tuneable mechanisms, including hydrodynamic, electrophoresis, dielectrophoresis, magnetophoresis, acoustophoresis, thermophoresis and optical forces. These mechanisms are applied to obtain desired bioparticle motions which are important in facilitating different biological processes. In this work, we review the fundamentals, features and applications of these tuneable mechanisms for the manipulation of bioparticles such as proteins, nucleic acids, viruses, bacteria, stem cells, cancer and tumor cells, blood cells and multicellular organisms in microfluidic systems. We focus on applications that can realize biomedical devices potentially suitable in diagnostic, therapeutic or analytical applications. Future perspectives of microfluidic systems incorporating active bioparticle manipulation mechanisms are included.
Subject Materials Engineering not elsewhere classified
DOI - identifier 10.1039/C6RA20080J
Copyright notice © The Royal Society of Chemistry 2016
ISSN 2046-2069
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