Making a hydrophoretic focuser tunable using a diaphragm

Yan, S, Zhang, J, Chen, H, Alici, G, Du, H, Zhu, Y and Li, W 2014, 'Making a hydrophoretic focuser tunable using a diaphragm', Biomicrofluidics, vol. 8, no. 6, pp. 1-12.


Document type: Journal Article
Collection: Journal Articles

Title Making a hydrophoretic focuser tunable using a diaphragm
Author(s) Yan, S
Zhang, J
Chen, H
Alici, G
Du, H
Zhu, Y
Li, W
Year 2014
Journal name Biomicrofluidics
Volume number 8
Issue number 6
Start page 1
End page 12
Total pages 12
Publisher A I P Publishing LLC
Abstract Microfluidic diagnostic devices often require handling particles or cells with different sizes. In this investigation, a tunable hydrophoretic device was developed which consists of a polydimethylsiloxane (PDMS) slab with hydrophoretic channel, a PDMS diaphragm with pressure channel, and a glass slide. The height of the hydrophoretic channel can be tuned simply and reliably by deforming the elastomeric diaphragm with pressure applied on the pressure channel. This operation allows the device to have a large operating range where different particles and complex biological samples can be processed. The focusing performance of this device was tested using blood cells that varied in shape and size. The hydrophoretic channel had a large cross section which enabled a throughput capability for cell focusing of ~15 000 cells s -1 , which was more than the conventional hydrophoretic focusing and dielectrophoresis (DEP)-active hydrophoretic methods. This tunable hydrophoretic focuser can potentially be integrated into advanced lab-on-a-chip bioanalysis devices.
Subject Medical Biotechnology not elsewhere classified
Keyword(s) Deterministic Lateral Displacement
Blood-Plasma Separation
Particle Separation
Microfluidics
Filtration
Size
Fractionation
Microchannel
Sheathless
Obstacles
DOI - identifier 10.1063/1.4903761
Copyright notice © 2014 AIP Publishing LLC.
ISSN 1932-1058
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