Arrays of polyacrylamide hydrogels using a carbodiimide-mediated crosslinking reaction

Qi, S, Tian, W, Lapierre, F, Song, G, Mulder, R, Zhu, Y, Kozielski, K and Wood, C 2014, 'Arrays of polyacrylamide hydrogels using a carbodiimide-mediated crosslinking reaction', Journal of Applied Polymer Science, vol. 131, no. 12, pp. 1-11.


Document type: Journal Article
Collection: Journal Articles

Title Arrays of polyacrylamide hydrogels using a carbodiimide-mediated crosslinking reaction
Author(s) Qi, S
Tian, W
Lapierre, F
Song, G
Mulder, R
Zhu, Y
Kozielski, K
Wood, C
Year 2014
Journal name Journal of Applied Polymer Science
Volume number 131
Issue number 12
Start page 1
End page 11
Total pages 11
Publisher John Wiley
Abstract This study introduces a radical-free approach for generating polyacrylamide (PAM) hydrogels with no toxic residues remaining in the networks. Acrylamide and bisacrylamide, which are neurotoxins, are not used during the hydrogel synthesis and only nontoxic side products are generated. This is achieved using a gentle carbodiimide-mediated crosslinking (CMCL) reaction that does not require complex initiation systems and is effective in the presence of oxygen. This overcomes some of the key limitations related to PAM hydrogel synthesis using free-radical routes and maintains the advantages of synthetic hydrogels over biopolymers. In addition, the CMCL reaction allows for accurate placement of functional groups, which controls hydrogel structure and performance including mechanical strength, swelling capacity, and hydrophobic balance. This flexibility is demonstrated through the synthesis and rheological characterization of a library of structurally diverse hydrogels as well as spherical hydrogels. PAM-based hydrogels are used extensively in a broad number of applications, and this study demonstrates the applicability of this method as a nontoxic and radical-free complementary alternative route that can generate structures analogous to those prepared using free-radical routes.
Subject Chemical Engineering not elsewhere classified
Keyword(s) crosslinking
gels
microfluidics
microgels
rheology
DOI - identifier 10.1002/app.40416
Copyright notice © 2014 Wiley Periodicals, Inc.
ISSN 0021-8995
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