Electrospun antibacterial nanofibers: Production, activity, and in vivo applications

Gao, Y, Truong, Y, Zhu, Y and Kyratzis, I 2014, 'Electrospun antibacterial nanofibers: Production, activity, and in vivo applications', Journal of Applied Polymer Science, vol. 131, no. 18, pp. 9041-9053.

Document type: Journal Article
Collection: Journal Articles

Title Electrospun antibacterial nanofibers: Production, activity, and in vivo applications
Author(s) Gao, Y
Truong, Y
Zhu, Y
Kyratzis, I
Year 2014
Journal name Journal of Applied Polymer Science
Volume number 131
Issue number 18
Start page 9041
End page 9053
Total pages 13
Publisher John Wiley
Abstract Electrospinning is an economical and relatively simple method to produce continuous and uniform nanofibers from almost any synthetic and many natural polymers. Because of the high specific surface area, tunable pore size, and flexibility, the nanofibrous membranes are finding an increasingly wide range of applications. Some particular attention has been devoted to antibacterial nanofibers for applications such as wound dressings. A variety of biocides, e.g., antibiotics, quaternary ammonium salts, triclosan, biguanides, (silver, titanium dioxide, and zinc oxide) nanoparticles and chitosan have been incorporated by various techniques into nanofibers that exhibit strong antibacterial activity in standard assays. However, the small diameters of the nanofibers also mean that the incorporated biocides are often burst released once the materials are submerged in an aqueous solution. Nevertheless, several strategies, such as core-sheath structure of the nanofiber, covalent bonding of the biocide on the fiber surface and adsorption of the biocide in nanostructures, can be utilized to sustain the release over several days. This review summarizes recent development in the fabrication of antibacterial nanofibers, the release profiles of the biocides and their applications in in vivo systems.
Subject Nanotechnology not elsewhere classified
Keyword(s) electrospinning
functionalization of polymers
DOI - identifier 10.1002/app.40797
Copyright notice Copyright © 2014 Wiley Periodicals, Inc.
ISSN 0021-8995
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