Preparation and antifouling property of polyurethane film modified by chondroitin sulfate

Yuan, H, Xue, J, Qian, B, Chen, H, Zhu, Y and Lan, M 2017, 'Preparation and antifouling property of polyurethane film modified by chondroitin sulfate', Applied Surface Science, vol. 394, pp. 403-413.

Document type: Journal Article
Collection: Journal Articles

Title Preparation and antifouling property of polyurethane film modified by chondroitin sulfate
Author(s) Yuan, H
Xue, J
Qian, B
Chen, H
Zhu, Y
Lan, M
Year 2017
Journal name Applied Surface Science
Volume number 394
Start page 403
End page 413
Total pages 11
Publisher Elsevier
Abstract An antifouling polyurethane film modified by chondroitin sulfate (PU-CS) was prepared by chemical grafting with N-Boc-1,3-propanediamine as a spacer. The different mass fraction of N-Boc-1,3-propanediamine was investigated to obtain PU-CS films with different CS grafting density. The surface properties of PU-CS films were comprehensively characterized. Proteins adsorption and glycosaminoglycans adhesion on films were evaluated. Moreover, inorganic salt deposition on film with highest CS grafting density (3.70 μg/cm 2 ) was briefly investigated. The results showed that the increase of CS grafting density improved not only the hydrophilicity but the antifouling performance of films. The best antifouling film reduced the adsorption of fibrinogen (BFG), human serum albumin (HSA) and lysozyme (LYS) by 81.4%, 95.0% and 76.5%, respectively, and the adhesion of chondroitin (CS), heparin (HP) and hyaluronic acid (HA) by 70.6%, 87.4% and 81.3%, respectively. In addition, the co-adsorption of proteins and glycosaminoglycans reduced up to 86.9% and 75.5%, respectively. Changes in inorganic salt deposition after co-adsorption of proteins and glycosaminoglycans on PU-CS(3) suggested that the proteins promoted the inorganic salt deposition, while glycosaminoglycans inhibited the crystal growth. The negatively charged polysaccharides might promote the generation of smaller crystals which could be conducive to provide theoretical and practical guide to develop novel urinary stents with significant anti-encrustation properties.
Subject Chemical Engineering not elsewhere classified
Keyword(s) Chondroitin sulfate
Glycosaminoglycan adhesion
Inorganic salt deposition
Polyurethane modification
Protein adsorption
DOI - identifier 10.1016/j.apsusc.2016.10.083
Copyright notice © 2016 Elsevier B.V. All rights reserved.
ISSN 0169-4332
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