High-fat diet worsens the impact of aging on microglial function and morphology in a region-specific manner

Spencer, S, Basri, B, Sominsky, L, Soch, A, Ayala, M, Reineck, P, Gibson, B and Barrientos, R 2019, 'High-fat diet worsens the impact of aging on microglial function and morphology in a region-specific manner', Neurobiology of Aging, vol. 74, pp. 121-134.


Document type: Journal Article
Collection: Journal Articles

Title High-fat diet worsens the impact of aging on microglial function and morphology in a region-specific manner
Author(s) Spencer, S
Basri, B
Sominsky, L
Soch, A
Ayala, M
Reineck, P
Gibson, B
Barrientos, R
Year 2019
Journal name Neurobiology of Aging
Volume number 74
Start page 121
End page 134
Total pages 14
Publisher Elsevier
Abstract Hippocampal microglia are vulnerable to the effects of aging, displaying a primed phenotype and hyper-responsiveness to various stimuli. We have previously shown that short-term high-fat diet (HFD) significantly impairs hippocampal- and amygdala-based cognitive function in the aged without affecting it in the young. Here, we assessed if morphological and functional changes in microglia might be responsible for this. We analyzed hippocampus and amygdala from young and aging rats that had been given three days HFD, a treatment sufficient to cause both hippocampal- and amygdala-dependent cognitive and neuroinflammatory differences in the aged. Aging led to the expected priming of hippocampal microglia in that it increased microglial numbers and reduced branching in this region. Aging also increased microglial phagocytosis of microbeads in the hippocampus, but the only effect of HFD in this region was to increase the presence of enlarged synaptophysin boutons in the aged, indicative of neurodegeneration. In the amygdala, HFD exacerbated the effects of aging on microglial priming (morphology) and markedly suppressed phagocytosis without notably affecting synaptophysin. These data reveal that, like the hippocampus, the amygdala displays aging-related microglial priming. However, the microglia in this region are also uniquely vulnerable to the detrimental effects of short-term HFD in aging.
Subject Neurology and Neuromuscular Diseases
Animal Neurobiology
Keyword(s) Microglia
Synaptophysin
Aging
High-fat diet
DOI - identifier 10.1016/j.neurobiolaging.2018.10.018
Copyright notice © 2018 Elsevier Inc. All rights reserved.
ISSN 0197-4580
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