Molecular mechanisms of immunoreceptors in platelets

Kuriri, F, O'Malley, C and Jackson, D 2019, 'Molecular mechanisms of immunoreceptors in platelets', Thrombosis Research, vol. 176, pp. 108-114.


Document type: Journal Article
Collection: Journal Articles

Title Molecular mechanisms of immunoreceptors in platelets
Author(s) Kuriri, F
O'Malley, C
Jackson, D
Year 2019
Journal name Thrombosis Research
Volume number 176
Start page 108
End page 114
Total pages 7
Publisher Elsevier
Abstract Background: The main role of platelets is to control haemostasis when there is a blood vessel injury in order to minimise blood loss at the injury site. Under normal circumstances, platelets flow freely within blood vessels as the endothelial cells provide a non-adhesion surface. Naturally, bioactive mediators are released from endothelial cells to prevent and control platelet activation. However, when the vascular endothelium is ruptured, the local concentration of nitric oxide and prostaglandin is diminished and receptors containing a sequence of amino acids known as, immunoreceptor tyrosine-based inhibition motifs (ITIMs), serve as natural inhibitors within platelets. The main role of ITIMs is to decrease immunoreceptor tyrosine-based activation motif (ITAM) signalling in platelets; however, some studies have revealed their novel role in integrin αIIbβ3 activation. This review highlights the main structural and functional features of immunoreceptors in platelets.
Subject Cardiovascular Medicine and Haematology not elsewhere classified
Haematology
Keyword(s) platelets
ITAM
ITAM
haemostasis
integrin αIIbβ3
DOI - identifier 10.1016/j.thromres.2019.01.019
Copyright notice Crown Copyright © 2019 Published by Elsevier Ltd. All rights reserved.
ISSN 0049-3848
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