Solubility Measurement, Modeling, and Thermodynamic Functions for para-Methoxyphenylacetic Acid in Pure and Mixed Organic and Aqueous Systems

Tangirala, R, De, D, Aniya, V, Bankupalli, S, Thella, P, Madapusi, S and Parthasarathy, R 2018, 'Solubility Measurement, Modeling, and Thermodynamic Functions for para-Methoxyphenylacetic Acid in Pure and Mixed Organic and Aqueous Systems', Journal of Chemical and Engineering Data, vol. 63, no. 9, pp. 3369-3381.


Document type: Journal Article
Collection: Journal Articles

Title Solubility Measurement, Modeling, and Thermodynamic Functions for para-Methoxyphenylacetic Acid in Pure and Mixed Organic and Aqueous Systems
Author(s) Tangirala, R
De, D
Aniya, V
Bankupalli, S
Thella, P
Madapusi, S
Parthasarathy, R
Year 2018
Journal name Journal of Chemical and Engineering Data
Volume number 63
Issue number 9
Start page 3369
End page 3381
Total pages 13
Publisher American Chemical Society
Abstract The solubility of para-methoxyphenylacetic acid in different solvents is of critical significance for the design and optimization of its purification process via crystallization. The present study illustrates new solidliquid phase equilibrium data of para-methoxy phenyl acetic acid in water, acetonitrile, propan-2-ol, morpholine, toluene, anisole, and binary (propan-2-ol + water, propan-2-ol + toluene) mixed solvents using a static analytical method from 283.15 to 323.15 K at atmospheric pressure. The highest solubility of para-methoxyphenylacetic acid was observed in propan-2-ol and lowest in water, with the maximum solubility effect for propan-2-ol + toluene binary system obtained at 0.5001 solute-free mole fraction of propan-2-ol. The modified Apelblat equation, λh (Buchowski) equation, and nonrandom two-liquid (NRTL) activity coefficient model were used to correlate the experimental solubility data in pure solvents, whereas the binary solvent systems were modeled using the vant HoffJouybanAcree, ApelblatJouybanAcree, and NRTL models, among which the NRTL model exhibited better goodness of fit. Also, for insight into the molecular interactions in the solvent systems, the enthalpy of dissolution has been being evaluated.
Subject Chemical Engineering not elsewhere classified
DOI - identifier 10.1021/acs.jced.8b00271
Copyright notice © 2018 American Chemical Society
ISSN 0021-9568
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