Structure Analysis of Solid Lipid Nanoparticles for Drug Delivery: A Combined USANS/SANS Study

Shah, R, Mata, J, Bryant, G, de Campo, L, Ife, A, Karpe, A, Jadhav, S, Eldridge, D, Palombo, E and Harding, I 2019, 'Structure Analysis of Solid Lipid Nanoparticles for Drug Delivery: A Combined USANS/SANS Study', Particle and Particle Systems Characterization, vol. 36, no. 1, pp. 1-7.


Document type: Journal Article
Collection: Journal Articles

Title Structure Analysis of Solid Lipid Nanoparticles for Drug Delivery: A Combined USANS/SANS Study
Author(s) Shah, R
Mata, J
Bryant, G
de Campo, L
Ife, A
Karpe, A
Jadhav, S
Eldridge, D
Palombo, E
Harding, I
Year 2019
Journal name Particle and Particle Systems Characterization
Volume number 36
Issue number 1
Start page 1
End page 7
Total pages 7
Publisher Wiley - V C H Verlag GmbH & Co. KGaA
Abstract Suspensions of solid lipid nanoparticles (SLNs) stabilized with emulsifiers have been extensively investigated (since the 1990s) as drug carriers, although details of their ultrastructure are poorly defined. Previously, a novel microwave-assisted microemulsion-based technique to prepare SLNs was reported. To understand the detailed internal structure of these SLNs, ultra-small angle neutron scattering (USANS) and small angle neutron scattering (SANS) experiments are conducted on suspensions of hydrogenated stearic acid SLNs stabilized with hydrogenated Tween 20 surfactant in D2O. Together, SANS and USANS gives a combined Q range of 0.000047 to 0.6 Å−1 (corresponding to a size range of ≈1 nm15 µm). This extended Q range allows a comprehensive understanding of the hierarchical structure of SLNs. The data are consistent with the multi-length scale structure of SLNs having polydispersed large particles with roughened surfaces at the microscale level. At the nanoscale level, the results are consistent with the SLNs having an ellipsoidal shape intermediate between spheres and rods, with a crossover from mass fractals to surface fractals. The elucidation of this structure is particularly important given that the structure influences the stability and drug release properties of the nanoparticles. These results assist in the development of systems with desired shape and properties.
Subject Nanotechnology not elsewhere classified
Soft Condensed Matter
DOI - identifier 10.1002/ppsc.201800359
Copyright notice © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
ISSN 0934-0866
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