Impacts of the High Moisture Wet Granulation and Novel Microwave Drying on the Textural Characteristics of Pharmaceutical Particles

Al-Ali, M, Alsamarrae, A, Salih, K, Periasamy, S and Parthasarathy, R 2018, 'Impacts of the High Moisture Wet Granulation and Novel Microwave Drying on the Textural Characteristics of Pharmaceutical Particles', in Proceedings of the 1st International Conference on Materials Engineering and Science (IConMEAS 2018), Istanbul, Turkey, 8-9 August 2018, pp. 1-7.


Document type: Conference Paper
Collection: Conference Papers

Title Impacts of the High Moisture Wet Granulation and Novel Microwave Drying on the Textural Characteristics of Pharmaceutical Particles
Author(s) Al-Ali, M
Alsamarrae, A
Salih, K
Periasamy, S
Parthasarathy, R
Year 2018
Conference name IConMEAS 2018
Conference location Istanbul, Turkey
Conference dates 8-9 August 2018
Proceedings title Proceedings of the 1st International Conference on Materials Engineering and Science (IConMEAS 2018)
Publisher Institute of Physics Publishing
Place of publication Australia
Start page 1
End page 7
Total pages 7
Abstract Naproxen sodium is a common non-steroidal anti-inflammatory drug used as a painkiller or in the therapy of rheumatoid and arthritic diseases. Naproxen sodium is a dipole drug with high affinity towards the water. Therefore, this study aimed to investigate the impacts of high moisture content due to wet granulation, and drying processes on the textural properties of naproxen sodium powder. In the present work, a new formulation of naproxen sodium drug was prepared and moisturized to 50 wt% by wet granulation process. Microwave radiation was employed to dry the high moisturized wet granules of naproxen sodium powder. Powder X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), and scanning electron microscope (SEM) were used to characterize samples before and after wet granulation and drying. The results showed that the crystalline structure, the morphology, and the chemical groups of the dry drug powder are remarkably changed after wet granulation. Microwave drying also affected the textural properties of the dried particles with no significant change in the chemical structure.
Subjects Powder and Particle Technology
Keyword(s) microwave drying
wet granulation
naproxen sodium
crystallinity
particle morphology
characterization
DOI - identifier 10.1088/1757-899X/454/1/012056
Copyright notice © Creative Commons Attribution 3.0 licence.
ISSN 1757-8981
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