Wall-free modelling of atherosclerosis growth

Gabriel, S, Ding, Y, Feng, Y and Gear, J 2015, 'Wall-free modelling of atherosclerosis growth', in Perumal Nithiarasu, Elisa Budyn, Etienne Boileau, Igor Sazonov and Xianghua Xie (ed.) CMBE15 - 4th International Conference on Computational & Mathematical Biomedical Engineering, Cachan, France, 29 June - 01 July 2015, pp. 164-167.


Document type: Conference Paper
Collection: Conference Papers

Title Wall-free modelling of atherosclerosis growth
Author(s) Gabriel, S
Ding, Y
Feng, Y
Gear, J
Year 2015
Conference name CMBE 2015 - 4th International Conference on Computational and Mathematical Biomedical Engineering
Conference location Cachan, France
Conference dates 29 June - 01 July 2015
Proceedings title CMBE15 - 4th International Conference on Computational & Mathematical Biomedical Engineering
Editor(s) Perumal Nithiarasu, Elisa Budyn, Etienne Boileau, Igor Sazonov and Xianghua Xie
Publisher CMBE
Place of publication Swansea, United Kingdom
Start page 164
End page 167
Total pages 4
Abstract This study presents a computational model, describing the formation and subsequent growth of atherosclerosis in its early stages. It is known that progressive mass aggregate of low-density lipoproteins (LDL) is an integral driving factor for the inflammatory process involved in atherosclerosis. Therefore, with the purpose of reducing computational costs for the evaluation of atherosclerosis distributions, the presented study models atherosclerosis growth as proportional to LDL aggregate. In doing so, the inflammatory process is not considered, and so mass conservation and a viable timescale are not realized. However, the model is shown to be effective for cases where time is not a variable of interest, and only the spatial distribution of atherosclerosis is sought. The model is tested on a two-dimensional bifurcating artery section, and is shown to provide satisfactory prediction of atherosclerosis lesion distributions.
Subjects Numerical and Computational Mathematics not elsewhere classified
Biological Mathematics
Keyword(s) atherosclerosis
growth
computational model
low density lipoprotein (LDL)
Copyright notice © 2015 by the authors of the abstracts
ISSN 2227-9385
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