Development of the cerebral cortex and the effect of the intrauterine environment

Quezada Rojas, S, Castillo-Melendez, M, Walker, D and Tolcos, M 2018, 'Development of the cerebral cortex and the effect of the intrauterine environment', Journal of Physiology, vol. 596, no. 23, pp. 5665-5674.


Document type: Journal Article
Collection: Journal Articles

Title Development of the cerebral cortex and the effect of the intrauterine environment
Author(s) Quezada Rojas, S
Castillo-Melendez, M
Walker, D
Tolcos, M
Year 2018
Journal name Journal of Physiology
Volume number 596
Issue number 23
Start page 5665
End page 5674
Total pages 10
Publisher Wiley-Blackwell Publishing
Abstract The human brain is one of the most complex structures currently under study. Its external shape is highly convoluted, with folds and valleys over the entire surface of the cortex. Disruption of the normal pattern of folding is associated with a number of abnormal neurological outcomes, some serious for the individual. Most of our knowledge of the normal development and folding of the cerebral cortex (gyrification) focuses on the internal, biological (i.e. genetically driven) mechanisms of the brain that drive gyrification. However, the impact of an adverse intrauterine and maternal physiological environment on cortical folding during fetal development has been understudied. Accumulating evidence suggests that the state of the intrauterine and maternal environment can have a significant impact on gyrification of the fetal cerebral cortex. This review summarises our current knowledge of how development in a suboptimal intrauterine and maternal environment can affect the normal development of the folded cerebral cortex.
Subject Foetal Development and Medicine
Neurosciences not elsewhere classified
Keyword(s) brain development
gyrification
intrauterine growth restriction
DOI - identifier 10.1113/jp277151
Copyright notice © 2018 The Authors
ISSN 0022-3751
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