Microstructure, mechanical properties, biocompatibility, and in vitro corrosion and degradation behavior of a new Zn5Ge alloy for biodegradable implant materials

Tong, X, Zhang, D, Zhang, X, Li, Y and Wen, C., et al, 2018, 'Microstructure, mechanical properties, biocompatibility, and in vitro corrosion and degradation behavior of a new Zn5Ge alloy for biodegradable implant materials', Acta Biomaterialia, vol. 82, pp. 197-204.


Document type: Journal Article
Collection: Journal Articles

Title Microstructure, mechanical properties, biocompatibility, and in vitro corrosion and degradation behavior of a new Zn5Ge alloy for biodegradable implant materials
Author(s) Tong, X
Zhang, D
Zhang, X
Li, Y
Wen, C., et al,
Year 2018
Journal name Acta Biomaterialia
Volume number 82
Start page 197
End page 204
Total pages 8
Publisher Elsevier BV
Abstract Zinc (Zn)-based alloys are considered a new class of biodegradable implant materials due to their superior chemical stability and processability compared to biodegradable magnesium (Mg) alloys. In this study, we report a new biodegradable Zn5Ge alloy with highly desirable mechanical, corrosion, and biological properties. Microstructural characterization revealed the effective grain-refining effect of germanium (Ge) on the Zn alloy. Tensile test results indicated that the hot-rolled Zn5Ge alloy showed an ultimate tensile strength of 237.0 MPa, a yield strength of 175.1 MPa, and an elongation of 21.6%; while as-cast pure Zn showed an ultimate tensile strength of 33.6 MPa, a yield strength of 29.3 MPa, and an elongation of 1.2%. The corrosion rates measured by potentiodynamic polarization tests in Hank's solution in ascending order are: as-cast Zn5Ge (0.1272 mm/y) < as-cast pure Zn (0.1567 mm/y) < hot-rolled Zn5Ge (0.2255 mm/y) < hot-rolled pure Zn (0.3057 mm/y). Immersion tests revealed that the degradation rate of as-cast Zn5Ge is 0.042 mm/y, less than half of that of hot-rolled pure Zn and ∼62% of that of as-cast pure Zn. Moreover, the Zn5Ge alloy showed excellent in vitro hemocompatibility and the addition of 5% Ge effectively enhanced the hemocompatibility of pure Zn. CCK-8 assay using murine preosteoblast MC3T3-E1 cells indicated that the diluted extracts at a concentration <12.5% of both the as-cast Zn5Ge alloy and pure Zn showed grade 0 cytotoxicity; the diluted extracts at the concentrations of 50% and 25% of Zn-5Ge alloy showed a significantly higher cell viability than those of pure Zn. Statement of Significance: Zinc (Zn)-based alloys are currently considered a new class of biodegradable implant materials due to their excellent processability. Here, we report a novel Zn5Ge alloy with highly desirable mechanical, corrosion and biological properties. The tensile test results indicated that the hot-rolled Zn5Ge alloy showed an ultimate tensile strengt
Subject Biomaterials
Metals and Alloy Materials
Keyword(s) ZnGe alloy
Biodegradable materials
Corrosion resistance
Mechanical properties
DOI - identifier 10.1016/j.actbio.2018.10.015
Copyright notice © 2018 Acta Materialia Inc.
ISSN 1742-7061
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 6 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 0 times in Scopus Article
Altmetric details:
Access Statistics: 7 Abstract Views  -  Detailed Statistics
Created: Mon, 29 Apr 2019, 13:04:00 EST by Catalyst Administrator
© 2014 RMIT Research Repository • Powered by Fez SoftwareContact us